Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases

International Journal of Colorectal Disease
Susanna NikolausStefan Schreiber

Abstract

Interleukin-6 (IL-6) production and signalling are increased in the inflamed mucosa in inflammatory bowel diseases (IBD). As published serum levels of IL-6 and its soluble receptors sIL-6R and sgp130 in IBD are from small cohorts and partly contradictory, we systematically evaluated IL-6, sIL-6R and sgp130 levels as markers of disease activity in Crohn's disease (CD) and ulcerative colitis (UC). Consecutive adult outpatients with confirmed CD or UC were included, and their disease activity and medication were monitored. Serum from 212 CD patients (815 measurements) and 166 UC patients (514 measurements) was analysed, and 100 age-matched healthy blood donors were used as controls. IL-6 serum levels were significantly elevated in active versus inactive CD and UC, also compared with healthy controls. However, only a fraction of IBD patients showed increased serum IL-6. IL-6 levels ranged up to 32.7 ng/mL in active CD (> 5000-fold higher than in controls), but also up to 6.9 ng/mL in inactive CD. Increases in active UC (up to 195 pg/mL) and inactive UC (up to 27 pg/mL) were less pronounced. Associations between IL-6 serum levels and C-reactive protein concentrations as well as leukocyte and thrombocyte counts were observed. Median ...Continue Reading

References

Jan 1, 1992·Immunopharmacology and Immunotoxicology·M MaedaY Niitsu
Jan 1, 1991·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·T AndusJ Schölmerich
Feb 1, 1991·Journal of Pediatric Gastroenterology and Nutrition·J S HyamsR E Moore
Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Mar 8, 1980·Lancet·R F Harvey, J M Bradshaw
Aug 1, 1993·Journal of Clinical Pathology·S NichollsT T MacDonald
Dec 10, 1997·European Journal of Gastroenterology & Hepatology·E LouisJ Y Mary
Nov 12, 2002·The American Journal of Gastroenterology·Yuriko TsukadaNaoaki Hayashi
Mar 5, 2003·The Journal of Biological Chemistry·Paola LovatoNiels Ødum
Jun 30, 2004·Scandinavian Journal of Gastroenterology·S Vadstrup
Jan 19, 2005·The American Journal of Gastroenterology·Jonas MudterMarkus F Neurath
Mar 9, 2005·Gut·T GustotD Franchimont
Jun 6, 2007·Digestive Diseases and Sciences·Stéphane NanceyBernard Flourie
Oct 17, 2009·Digestive Diseases and Sciences·Farid LjucaNada Pavlovic-Calic
Feb 18, 2010·Cell Cycle·Clemens NeufertChristoph Becker
Dec 12, 2013·Seminars in Immunology·Jürgen SchellerStefan Rose-John
Jan 23, 2014·Seminars in Immunology·Maximilian J Waldner, Markus F Neurath
May 7, 2014·Journal of Pediatric Gastroenterology and Nutrition·Alka GoyalDavid J Keljo
Jun 27, 2014·Clinical Medicine Insights. Gastroenterology·Maria CappelloPiero Luigi Almasio
Dec 11, 2014·Journal of Pediatric Gastroenterology and Nutrition·Antoinette J PusateriWallace V Crandall
Mar 10, 2015·Current Opinion in Immunology·Christoph GarbersStefan Rose-John
Apr 22, 2015·Nature Immunology·Christopher A Hunter, Simon A Jones
Apr 30, 2015·European Journal of Gastroenterology & Hepatology·Torsten SchröderJürgen Büning
Jul 21, 2015·Cytokine & Growth Factor Reviews·Fred Schaper, Stefan Rose-John
Nov 30, 2016·World Journal of Gastroenterology : WJG·Ulrike BillmeierRaja Atreya
Jun 24, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Gesine RichterAlena Buyx

❮ Previous
Next ❯

Citations

Aug 26, 2020·Inflammatory Bowel Diseases·Amy C PorterJohn-Michael Sauer
Jun 27, 2019·American Journal of Physiology. Endocrinology and Metabolism·Samadhi Aparicio-SiegmundChristoph Garbers
Oct 8, 2019·Expert Opinion on Therapeutic Targets·Sare VerstocktSéverine Vermeire
Jun 10, 2021·Inflammatory Bowel Diseases·Gabrielle BoucherUNKNOWN NIDDK IBD Genetics Consortium

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Kiel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.