Evaluation of Interleukin-9 Expression as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia in a Cohort of Egyptian Patients

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
Hadeer A AbbassyOmar M Ghallab

Abstract

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy that has a highly variable clinical course. Genomic features as zeta-chain-associated protein kinase 70 (ZAP70) expression and CD38 expression provide further differentiation of disease prognosis. Extensive studies have confirmed the oncogenic activities of IL-9 in lymphoma. The aim of the current study was to investigate the contribution of IL-9 expression to the pathogenesis of CLL and its correlation to other prognostic parameters. This study was conducted on 80 patients at diagnosis with CLL and 80 healthy controls. Using real time polymerase chain reaction and enzyme linked immunosorbant assay, IL-9 mRNA expression and its serum level were compared between patients and controls. They were both correlated with other prognostic factors. There was an overexpression of IL-9 in CLL patients that correlated with modified Rai staging, ZAP70, CD38 and all hallmarks of an active and aggressive disease. The correlation between IL-9 upregulation and patient characteristics provided direct clinical evidence for its contribution to the pathogenesis of CLL. In conclusion, significantly higher expression of IL-9 measured at both the mRNA and the protein levels in patients...Continue Reading

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J C RenauldJ Van Snick
Feb 1, 1980·Scandinavian Journal of Haematology·B SimonssonK Nilsson
Mar 20, 1998·International Reviews of Immunology·J B Demoulin, J C Renauld
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·M RichardJ Van Snick
Jan 17, 2004·Lancet·Jenny A OrchardDavid G Oscier
Feb 25, 2005·The New England Journal of Medicine·Nicholas ChiorazziManlio Ferrarini
Jul 16, 2005·Hematology·Zoltan Matrai
Dec 4, 2009·Nature Reviews. Cancer·Thorsten ZenzStephan Stilgenbauer
Apr 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Etienne MoussayDavid J Galas
Nov 16, 2013·Immunology Letters·Vijay Kumar

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