Evaluation of intra-articular injection of autologous platelet lysate (PL) in horses with osteoarthritis of the distal interphalangeal joint

The Veterinary Quarterly
Panagiota TyrnenopoulouGeorgios Koliakos

Abstract

Regenerative medicine has become one of the most promising therapies of equine osteoarthritis. Platelet lysate (PL) is rich in bioactive proteins and growth factors that play a crucial role in tissue healing. To evaluate the efficacy of intra-articularly injected autologous PL in equine athletes with naturally occurring osteoarthritis. Fifteen warmblood geldings aged 8-19 years with osteoarthritis of the distal interphalangeal joint were included in this study. They were randomly divided into two groups; 10 horses received intra-articular injections of PL and 5 of normal saline (controls). Before treatment, platelet-derived growth factor (PDGF) levels in basal plasma and prepared PL were estimated. Each joint was injected twice within a three-week period. Lameness was evaluated using the American Association of Equine Practitioners grading system, before treatment and 10 days after each intra-articular injection. Horses were examined fortnightly for one year. Radiographic examination was performed six months post-treatment. The generalized estimating equation test was used for statistical analysis. Acceptable levels of PDGF were detected in PLs (mean ± SD: 258.0 ± 52.3 pg/ml). The majority of horses (9/10) responded positively ...Continue Reading

References

Sep 1, 1988·Equine Veterinary Journal. Supplement·C W McIlwraith, A Vachon
Oct 18, 2001·Clinical Orthopaedics and Related Research·W B van den BergH M van Beuningen
Apr 2, 2002·The Journal of Bone and Joint Surgery. British Volume·L A FortierA J Nixon
Oct 3, 2003·Medicine and Science in Sports and Exercise·Mikel SánchezIñigo Mujika
Jan 8, 2005·Clinics in Sports Medicine·Andrew D PearleScott A Rodeo
Jan 24, 2006·The Veterinary Journal·Laurie R Goodrich, Alan J Nixon
Dec 1, 2006·European Cells & Materials·P J Roughley
Oct 22, 2008·Journal of Tissue Engineering and Regenerative Medicine·S H ZakyM Mastrogiacomo
Sep 29, 2009·Biomaterials·Nathalie ChevallierHelene Rouard
Oct 20, 2009·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Elizaveta KonMaurilio Marcacci
Aug 27, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Giuseppe FilardoMaurilio Marcacci
Mar 12, 2011·International Orthopaedics·Paola TorricelliRoberto Giardino
Mar 16, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Rosalyn T NguyenKelly McInnis
Mar 16, 2011·Clinical Orthopaedics and Related Research·Lisa A FortierBrian J Cole
Aug 23, 2011·The American Journal of Sports Medicine·Gerben M van BuulGerjo J V M van Osch
Aug 30, 2011·The Veterinary Clinics of North America. Equine Practice·Jamie Textor
Apr 25, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Tomokazu YoshiokaNaoyuki Ochiai
Oct 2, 2013·Nature Reviews. Rheumatology·Isabel Andia, Nicola Maffulli
Jul 16, 2014·International Journal of Rheumatology·Nidhi Sofat, Anasuya Kuttapitiya
Aug 29, 2014·Arthritis Research & Therapy·Xuetao XieRocky S Tuan

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Citations

Mar 24, 2018·Cellular & Molecular Biology Letters·Ghmkin HassanMajd Aljamali
Mar 22, 2019·Frontiers in Veterinary Science·Renata L LinardiKyla F Ortved
Jan 11, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jessica M GilbertieLauren V Schnabel
Sep 2, 2020·Trends in Biotechnology·Carla S SoaresManuela E Gomes
Feb 19, 2020·Journal of Equine Veterinary Science·Livia Camargo Garbin, Christine S Olver
Jan 23, 2021·Animals : an Open Access Journal From MDPI·Iris RibitschFlorien Jenner
Apr 20, 2021·Frontiers in Veterinary Science·Livia Camargo GarbinJorge U Carmona
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Lorenzo G T M SegabinazziIgor F Canisso
Jun 23, 2021·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Susanne P RothAntonia Troillet
Jul 30, 2021·Frontiers in Veterinary Science·Elena De AngelisPaolo Borghetti
Aug 4, 2021·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Angelo BoffaGiuseppe Filardo

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Methods Mentioned

BETA
enzyme-linked
ELISA

Software Mentioned

SPSS

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