Evaluation of Intradermal and Subcutaneous Infusion Set Performance Under 24-Hour Basal and Bolus Conditions

Journal of Diabetes Science and Technology
Elaine McVeyRonald J Pettis

Abstract

This study sought to assess the function and delivery reliability of intradermal (ID) infusion sets used with commercial insulin pumps. Healthy subjects (n = 43) were randomized to either ID or subcutaneous (SC) arms, and received basal/bolus placebo delivery for 24 hours. Subjects received 4 of 8 infusion set combinations (ID: microneedle design A or B, with 2 pump brands [Animas or MiniMed]; SC: Teflon Quickset or steel Rapid-D, Animas pump only, with or without overtaping) and were evaluated for pump occlusion alarms, fluid leakage, pain, and tissue tolerability. A novel algorithm was developed to determine flow consistency based on fluid pressure, and the duration and occurrence rate for periods of unalarmed but interrupted flow ("silent occlusions'") were compared. ID delivery was successfully maintained over the 24-hour infusion period. The number of silent occlusions was lower for ID microneedle cannula design B than A (P < .01) and lower for Rapid-D SC device compared to Quick-set (P = .03). There was no significant difference in the number of occlusion alarms between the ID and SC devices with the Animas pump. However, the pumps tested with ID devices had significantly different alarm rates (MiniMed 29.5%, Animas 0%, P...Continue Reading

References

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Apr 15, 2014·Annals of the New York Academy of Sciences·Thomas PeyserJay S Skyler

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Citations

Feb 18, 2016·Diabetes Technology & Therapeutics·Lutz Heinemann
Jun 4, 2015·Drug Delivery and Translational Research·Christopher James RiniRonald J Pettis
Sep 7, 2016·Mayo Clinic Proceedings·Anders H FridKenneth W Strauss
Mar 19, 2019·Journal of Diabetes Science and Technology·Christopher RiniRonald J Pettis
Dec 14, 2018·Journal of Diabetes Science and Technology·Ronald J PettisLutz Heinemann
Feb 13, 2021·Cells·Kevin VerhoeffAndrew Mark James Shapiro

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Software Mentioned

set
Animas
Quick
Rapid

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