Evaluation of intraocular reactivity to metallic and ethylene oxide contaminants of medical devices in a rabbit model

Ophthalmology
Don CalogeroMalvina B Eydelman

Abstract

To evaluate the intraocular reactivity to metallic and ethylene oxide (EO) contaminants of ophthalmic devices in rabbits. Two experimental animal studies. Thirty-five New Zealand white rabbits. A metallic exposure study and an EO exposure study were performed. In the first study, both eyes of 25 rabbits were equally allocated to intracameral injections of alumina 0.2 μg, alumina 20 μg, copper sulfate 0.4 μg, copper sulfate 20 μg, or an aqueous control. In the second study, 10 rabbits were allocated (5 per group) to receive intracamerally an ophthalmic viscosurgical device (OVD) exposed to EO or not exposed to EO (control). All eyes were examined by slit lamp at baseline and 3, 6, 9, 24, 48, and 72 hours after exposure, with dilated indirect ophthalmoscopy being performed at 24 and 72 hours. Tonometry was performed only in the first study. Grade of corneal clouding, anterior chamber (AC) flare, AC cells, AC fibrin, iridal hyperemia, cell and fibrin on the lens surface, vitreous haze and cells, lens opacities, intraocular pressure, and onset time. For metallic compounds at the study's low doses, mean inflammatory grades were 0.2 or less above the control for all responses at all time points. For the high-dose alumina, mean inflam...Continue Reading

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Citations

Jul 4, 2012·Ophthalmology·John D Gottsch, Oliver D Schein
May 15, 2012·Ophthalmology·Malvina B EydelmanKesia Y Alexander
Apr 12, 2016·Journal of Cataract and Refractive Surgery·Bennett N WalkerIlko K Ilev
Jun 10, 2015·American Journal of Ophthalmology·Takashi SuzukiKazunori Miyata
Feb 1, 2015·American Journal of Ophthalmology·Takashi SuzukiUNKNOWN Japanese Ophthalmological Society HOYA Intraocular Lens–Related Endophthalmitis Investigation Commission
Feb 18, 2015·Journal of Cataract and Refractive Surgery·Goichiro MiyakeAkihiko Shibuya
Sep 12, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Karny Shouchane-BlumNoa Geffen
Nov 30, 2018·Current Opinion in Ophthalmology·Karny Shouchane-BlumIrit Bahar
Jan 8, 2021·International Journal of Retina and Vitreous·Sukhum Silpa-ArchaJanine M Preble
Jul 30, 2021·Environmental Science and Pollution Research International·Guowei ZengKai-Hong Wu

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