Evaluation of intraocular reactivity to organic contaminants of ophthalmic devices in a rabbit model

Ophthalmology
Shelley Y BuchenMalvina B Eydelman

Abstract

To evaluate the intraocular reactivity to organic contaminants of ophthalmic devices in the rabbit. Experimental animal study. Fifty New Zealand white rabbits. The rabbits were allocated to 10 groups of 5 each to receive 2 different doses of human albumin and nonhuman nucleic acids and their respective vehicle controls, a denatured cohesive ophthalmic viscosurgical device (OVD) and a denatured dispersive OVD and their respective nondenatured controls. All 10 eyes in each treatment group received bilateral intracameral injection of the test materials. All the eyes in the study were examined by slit-lamp biomicroscopy at baseline and 6, 9, 24, 48, and 72 hours. Pachymetry was also performed on eyes exposed to albumin, protein vehicle control, and the OVDs at these time points. Corneal thickness, grade of corneal clouding, anterior chamber (AC), cells, flare and fibrin, iridal hyperemia, cell and fibrin on lens surface, and onset time. There were no inflammatory signs in any eyes exposed to human albumin. Anterior chamber cells (1+ to 3+) and flare and fibrin (1+ to 2+), along with cells and fibrin on the lens surface, were seen in the eyes exposed to the nucleic acid samples, and they resolved in 24 hours. Mild (mostly 1+) conjun...Continue Reading

References

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Jul 9, 2010·Journal of Cataract and Refractive Surgery·Carolee M Cutler PeckNick Mamalis

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Citations

Jul 4, 2012·Ophthalmology·John D Gottsch, Oliver D Schein
May 15, 2012·Ophthalmology·Malvina B EydelmanKesia Y Alexander
Mar 1, 2017·AORN Journal·Lisa Spruce

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