Evaluation of intraoperative parathormone measurement for predicting successful surgery in patients undergoing subtotal/total parathyroidectomy due to secondary hyperparathyroidism

The Laryngoscope
Melih KaraIzzet Titiz

Abstract

The aim of this study is to investigate the predictive value of intraoperative parathormone measurement addressing successful surgical resection in patients with secondary hyperparathyroidism. The study included 42 consecutive patients operated on between May 2006 and July 2008. Patients were grouped according to successful surgery (Group 1, n = 36) and persistent postoperative hyperparathyroidism (Group 2, n = 6). Serum phosphorus (P), total calcium (tCa), ionized calcium (iCa), intact parathormone (iPTH), and alkaline phosphatase (ALP) were drawn preoperatively and intraoperatively upon 15 minutes after completion of resection (iPTH(15)). The rate of decrease of pith detected by iPTH(15) compared to preoperative values was calculated (iPTH(%)). Preoperative P, tCa, iCa, iPTH, and ALP were comparable. Subtotal parathyroidectomy (sPx) (n = 27) and total parathyroidectomy with autotransplantation (tPx) (n = 15) were performed. Mean iPTH(15) value, iPTH(%) rates were 145.9 +/- 12.3 pg/mL, % 91.6 +/- 0.7, and 522.5 +/- 85.4 pg/mL, % 75.1 +/- 2.0 (P = ,001) in Groups 1 and 2, respectively. Mean serum tCa and iCa at POD#1 in Group 1 were 7.6 +/- 0.1 mg/dL, 0.910 +/- 0.4 mmol/L, and Group 2 were 8.3 +/- 0.3 mg/dL, 1.050 +/- 0.4 mmol/...Continue Reading

References

Jul 1, 1992·Mayo Clinic Proceedings·P C KaoS Khosla
May 1, 1988·The Australian and New Zealand Journal of Surgery·I R GoughF E Eckhauser
Mar 1, 1988·Annals of Surgery·M Rothmund, P K Wagner
Jul 1, 1995·Seminars in Nuclear Medicine·M McBilesS Y Kim
May 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F Llach
Jul 1, 1994·Seminars in Nuclear Medicine·J E Freitas, A E Freitas
May 1, 1994·Annals of Surgery·G L IrvinS K Chandarlapaty
Feb 1, 1993·Kidney International·D J SherrardG V Segre
Mar 1, 1997·Seminars in Surgical Oncology·Y TominagaH Takagi
May 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D N Cruz, M A Perazella
Jun 1, 1997·Journal of the American Society of Nephrology : JASN·A J Felsenfeld
Feb 19, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S StrackeF Keller
Jun 1, 2001·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A TrupkaR Landgraf
Mar 13, 2002·Archives of Surgery·Fong-Fu ChouShyr-Ming Sheen-Chen
May 2, 2002·Kidney International. Supplement·Angel L M de FranciscoM Arias
Dec 19, 2002·American Journal of Surgery·Stacy L StratmannTodd M McCarty
Jan 20, 2004·Ultrasound Quarterly·Nadia KhatiMichael C Hill
Mar 3, 2004·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Irme Akhtar, Esther A González
Apr 15, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Yoshihiro TominagaTetsuhiko Sato
Mar 6, 2007·The Journal of Surgical Research·Yoshifumi IkedaHiroshi Takami
Oct 28, 2008·World Journal of Surgery·Shih-Ping ChengTsen-Long Yang

❮ Previous
Next ❯

Citations

May 20, 2015·The Journal of Surgical Research·Sarah C OltmannDavid F Schneider
Sep 10, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Anda B Tuncay ScorzaLee A Bricker
Sep 17, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L-N ZhangN-N Wang
Nov 15, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Assia Ghani, Prudence Baxter
Jan 22, 2019·Head & Neck·Nathaniel J WalshDavid J Terris
Apr 26, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Fangyan XuNingning Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.