PMID: 8947903Nov 1, 1996Paper

Evaluation of ion-implanted-silicon detectors for use in intraoperative positron-sensitive probes

Medical Physics
R R Raylman, R L Wahl

Abstract

The continuing development of probes for use with beta (positron and electron) emitting radionuclides may result in more complete excision of tracer-avid tumors. Perhaps one of the most promising radiopharmaceuticals for this task is 18F-labeled-Fluoro-2-Deoxy-D-Glucose (FDG). This positron-emitting agent has been demonstrated to be avidly and rapidly absorbed by many human cancers. We have investigated the use of ion-implanted-silicon detectors in intraoperative positron-sensitive surgical probes for use with FDG. These detectors possess very high positron detection efficiency, while the efficiency for 511 keV photon detection is low. The spatial resolution, as well as positron and annihilation photon detection sensitivity, of an ion-implanted-silicon detector used with 18F was measured at several energy thresholds. In addition, the ability of the device to detect the presence of relatively small amounts of FDG during surgery was evaluated by simulating a surgical field in which some tumor was left intact following lesion excision. The performance of the ion-implanted-silicon detector was compared to the operating characteristics of a positron-sensitive surgical probe which utilizes plastic scintillator. In all areas of perfor...Continue Reading

Citations

Mar 28, 2007·Annals of Nuclear Medicine·Seiichi YamamotoMichio Senda
Mar 18, 2005·Annals of Nuclear Medicine·Seiichi YamamotoMichio Senda
Apr 14, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Barbara M FischerPaul E G Kristjansen
Apr 14, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Morand PiertMarkus Schwaiger
May 12, 2001·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·D C. DesaiE W. Martin
Jan 29, 2009·World Journal of Surgical Oncology·Stephen P PovoskiEdward W Martin
Jun 28, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A ChellaC A Angeletti

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