Evaluation of iron oxide nanoparticle micelles for magnetic particle imaging (MPI) of thrombosis

PloS One
Lucas W E StarmansHolger Grüll

Abstract

Magnetic particle imaging (MPI) is an emerging medical imaging modality that directly visualizes magnetic particles in a hot-spot like fashion. We recently developed an iron oxide nanoparticle-micelle (ION-Micelle) platform that allows highly sensitive MPI. The goal of this study was to assess the potential of the ION-Micelles for MPI-based detection of thrombi. To this aim, an in vivo carotid artery thrombosis mouse model was employed and ex vivo magnetic particle spectrometer (MPS) measurements of the carotid arteries were performed. In addition, we studied the effect of functionalization of the ION-Micelle nanoplatform with fibrin-binding peptides (FibPeps) with respect to nanoparticle thrombus uptake and hence thrombus detection. In vivo quantitative MR imaging pre- and post-ION-Micelle injection was performed as reference for visualization of ION-micelle uptake. ION-Micelles significantly decreased T2 values in the thrombi with respect to pre-injection T2 values (p < 0.01) and significantly increased ex vivo MPS thrombus signal with respect to the noninjured, contralateral carotid (p < 0.01). Functionalization of the ION-Micelles with the FibPep peptides did not result in an increased MPS thrombus signal with respect to th...Continue Reading

References

Jan 1, 1995·Angiology·A MarkelD Gaitini
Jul 1, 2005·Nature·Bernhard Gleich, Jürgen Weizenecker
Apr 13, 2006·The Journal of Pharmacology and Experimental Therapeutics·Feride CengelliLucienne Juillerat-Jeanneret
Jul 5, 2006·Circulation·Itzhak Kronzon, Paul A Tunick
Apr 14, 2007·Circulation Research·Ulrich J H Sachs, Bernhard Nieswandt
Oct 24, 2007·Physics in Medicine and Biology·J WeizeneckerB Gleich
Sep 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Martin LundqvistKenneth A Dawson
Sep 23, 2009·AJR. American Journal of Roentgenology·Diana LitmanovichPhillip M Boiselle
Mar 16, 2013·Annals of Neurology·Dong-Eog KimKwangmeyung Kim
Apr 23, 2013·Contrast Media & Molecular Imaging·Lucas W E StarmansHolger Grüll
Oct 9, 2013·Molecular Pharmaceutics·Lucas W E StarmansHolger Grüll
Nov 5, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Bram F CoolenGustav J Strijkers

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Citations

Feb 19, 2016·Iranian Red Crescent Medical Journal·Kazem ParivarMahsa Motavaf
Dec 4, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rik P M MoonenGustav J Strijkers
Jun 19, 2015·Advanced Healthcare Materials·Eun Ji Chung, Matthew Tirrell
Mar 30, 2016·Experimental Biology and Medicine·Eun Ji Chung
Jan 4, 2017·Chemical Reviews·Bryan Ronain Smith, Sanjiv Sam Gambhir
May 18, 2018·Medical Physics·Hafsa KhurshidJohn B Weaver
Jan 4, 2019·Nanoscale·Xiangjun HanKhashayar Farsad
Jan 19, 2019·AJNR. American Journal of Neuroradiology·L C WuM Wintermark
Mar 21, 2020·Advanced Healthcare Materials·Ali FarzinAli Tamayol
Mar 16, 2017·AIP Advances·Hafsa KhurshidJohn B Weaver
May 10, 2020·Topics in Current Chemistry·Ashish AvasthiMaría Luisa García-Martín
Dec 29, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Karla X Vazquez-PradaHang T Ta
Aug 14, 2020·Journal of Proteome Research·Amir Ata SaeiMorteza Mahmoudi
Jul 24, 2021·British Journal of Pharmacology·Xiaowei WangKarlheinz Peter

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Methods Mentioned

BETA
imaging techniques
dynamic
transmission electron microscopy
confocal microscopy

Software Mentioned

Mathematica

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