Evaluation of kidney damage in patients with acute lymphoblastic leukemia in long-term follow-up: value of renal scan

American Journal of Hematology
Sevgi YetginOsman Saraçbaşi

Abstract

In order to evaluate potential long-term kidney damage of childhood leukemia and risk factors affecting renal damage, we studied 116 children treated for acute lymphoblastic leukemia (ALL) using the St. Jude Total XI and XIII protocols in 1991-1998. The median follow-up period after the completion of treatment was 35 months. The following parameters were examined: urinalysis, urinary creatinine (Cr), calcium (Ca), phosphorus, beta2-microglobulin, glomerular filtration rate (GFR), tubular phosphorus reabsorption (TPR), and renal function tests. Radiological evaluation included renal ultrasonography (US), and renal scans with DMSA or MAG-3 were performed. Blood chemistry and renal US patients were normal in all patients except two. GFR, TPR, urinary Ca/Cr, beta2-microglobulin, and renal scan were abnormal in 19.0%, 16.4%, 13.8%, 6.0%, and 40.5% of patients, respectively. The abnormality rate in GFR was significantly higher in patients <2 years of age. TPR abnormality was found to be significantly higher in patients who did not have G-CSF. An abnormal renal scan was associated with Hb < 10 g/dL, kidney infiltration, or hypertension at presentation and also occurred patients who underwent methotrexate treatment with frequent interv...Continue Reading

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Citations

Mar 23, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maryna Krawczuk-RybakJolanta Wysocka
Sep 29, 2006·Journal of Pediatric Hematology/oncology·Seref OlgarTulin Aras
Jul 7, 2012·Journal of Pediatric Hematology/oncology·Paul GibsonAbha A Gupta
May 2, 2012·Case Reports in Medicine·Egle SimanauskieneGilvydas Verkauskas
Mar 24, 2010·Drug and Chemical Toxicology·Gürkan GencEmel Ozyürek
Jan 23, 2016·Pediatric Blood & Cancer·Matthew D RamirezKaren Wasilewski-Masker
Aug 3, 2011·Radiologic Clinics of North America·R Paul GuillermanBruce R Parker
Jul 6, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Patricia Seo-MayerGilbert W Moeckel
Jun 5, 2008·Pediatric Blood & Cancer·Marika H GrönroosToivo T Salmi
Jul 7, 2007·Pediatric Hematology and Oncology·Zühre KayaSuna Ozhan Oktar

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