Evaluation of kidney injury biomarkers in rat amniotic fluid after gestational exposure to cadmium

Journal of Applied Toxicology : JAT
Tania Jacobo-EstradaOlivier C Barbier

Abstract

Cadmium is a well-characterized nephrotoxic agent that is also capable of accumulating and diffusing across the placenta; however, only a few studies have addressed its effects over fetal kidneys and none of them has used a panel of sensitive and specific biomarkers for the detection of kidney injury. The goal of this study was to determine cadmium renal effects in rat fetuses by the quantification of early kidney injury biomarkers. Pregnant Wistar rats were exposed by inhalation to an isotonic saline solution or to CdCl2 solution (DDel =1.48 mg Cd kg(-1) day(-1) ) during gestational days (GD) 8-20. On GD 21, dams were euthanized and samples obtained. Kidney injury biomarkers were quantified in amniotic fluid samples and fetal kidneys were microscopically evaluated to search for histological alterations. Our results showed that cadmium exposure significantly raised albumin, osteopontin, vascular endothelial growth factor and tissue inhibitor of metalloproteinases-1 levels in amniotic fluid, whereas it decreased creatinine. Clusterin, calbindin and IFN-inducible protein 10 did not show any change. Accordingly, histological findings showed tubular damage and precipitations in the renal pelvis. In conclusion, gestational exposure ...Continue Reading

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Citations

Oct 11, 2016·Pediatric Research·Mandar S JoshiMina H Hanna
Jul 25, 2017·International Journal of Molecular Sciences·Tania Jacobo-EstradaOlivier Barbier
Nov 24, 2017·Particle and Fibre Toxicology·Cécile VignalMathilde Body-Malapel
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Antonio MicaliLetteria Minutoli
Oct 14, 2021·International Urology and Nephrology·Humairat H RahmanStuart H Munson-McGee

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