Evaluation of L-1-[18 F]Fluoroethyl-Tryptophan for PET Imaging of Cancer

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Yangchun XinHancheng Cai

Abstract

Fluorine-18 labeled tryptophan analog L-1-[18F]fluoroethyl-tryptophan (L-1-[18F]FETrp) was designed for positron emission tomography (PET) imaging of cancer by dual targeting of the overexpressed amino acid transporters and altered indoleamine 2,3-dioxygenase (IDO)-mediated kynurenine pathway of tryptophan metabolism. In our previous study, we described the radiosynthesis and preliminary evaluation of L-1-[18F]FETrp for PET imaging of breast cancer. The aim of this study was to investigate the in vivo imaging mechanism and further evaluate this radiotracer in more wide range types of cancers including prostate cancer, lung cancer, and glioma. The mice bearing subcutaneous PC-3 prostate cancer, subcutaneous H2009 and H460 lung cancers, subcutaneous MDA-MB-231, orthotopic A549 lung cancer, and intracranial 73C glioma were employed to evaluate L-1-[18F]FETrp for PET imaging of cancer. The in vivo catabolism of L-1-[18F]FETrp in the tumor was studied by analysis of PC-3 extracts with radio-HPLC. Small animal PET/CT imaging of L-1-[18F]FETrp visualized all tumors in these different mouse models with high accumulations of radioactivity in PC-3 (7.5 ± 0.6 % ID/g), H2009 (5.3 ± 0.8 % ID/g), H460 (9.0 ± 1.4 % ID/g), A549 (4.5 ± 0.5 % ID...Continue Reading

References

May 27, 2005·Seminars in Cancer Biology·Bryan C Fuchs, Barrie P Bode
Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Simonetta AstigianoGuido Frumento
Aug 19, 2007·Cancer Biology & Therapy·Vaios KaranikasAnastasios E Germenis
Jul 1, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christian Plathow, Wolfgang A Weber
Feb 19, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Csaba JuhászDiane C Chugani
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Nov 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jessica Godin-EthierRéjean Lapointe
Dec 27, 2011·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ting SunShihchen Wang
Feb 15, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Stefanie D KrämerSimon M Ametamey
Dec 15, 2012·Nature Reviews. Drug Discovery·László VécseiJózsef Toldi
Jan 30, 2015·Frontiers in Immunology·Michael PlattenKatharina Ochs
Jul 25, 2015·Journal of Medicinal Chemistry·Amy B DounayPatrick R Verhoest
Dec 18, 2015·Journal for Immunotherapy of Cancer·Yong Wha MoonAung Naing
May 7, 2016·Nuclear Medicine and Biology·Xuan HuangHaibin Tian
Oct 22, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sharon K MichelhaughSandeep Mittal
Nov 7, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yangchun Xin, Hancheng Cai
Mar 23, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lieve BrochezVibeke Kruse

❮ Previous
Next ❯

Citations

Sep 13, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Flóra JohnCsaba Juhász
Nov 7, 2019·EJNMMI Radiopharmacy and Chemistry·Peter WierstraSandra Heskamp
Feb 9, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ana Margarida AbrantesMaria Filomena Botelho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.