PMID: 11926556Apr 3, 2002Paper

Evaluation of lanreotide effects on human exocrine pancreatic secretion after a single dose: preliminary study

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
M FalconiP Pederzoli

Abstract

Total parenteral nutrition and somatostatin or analogues represent a consolidated therapeutic approach for external fistulas, a frequent complication of major pancreatic surgery. To establish the effects of the somatostatin analogue lanreotide on exocrine pancreatic secretion. Eight patients, undergoing pancreaticoduodenectomy for malignancy, were enrolled in the trial. The volume and composition of pancreatic secretion were evaluated after one single subcutaneous injection of lanreotide 0.5 mg or placebo in a randomised, double-blind cross-over trial. In the seven patients completing the study, the 24-h output volume was 208.6+/-41.3 and 253.9+/-72.4 ml after lanreotide and placebo, respectively. During the first 6 hours values were 48.1+/-14.7 and 77.6+/-21.4 ml (p=0. 02). No significant difference between treatments was detected in the qualitative composition of 24-h pancreatic secretion, although bicarbonate secretion remained lower after the active drug at all the observation intervals. Peak lanreotide levels were detected 15-30 min after drug injection. Clinical and laboratory tolerability was good. Lanreotide induced a statistically significant reduction in the output volume with respect to placebo in the first 6 hours a...Continue Reading

References

Dec 1, 1992·European Journal of Clinical Investigation·J M KuhnL M Wolf
Feb 1, 1991·American Journal of Surgery·J H Peters, L C Carey
Sep 1, 1989·Scandinavian Journal of Gastroenterology·A SaariM Lempinen
Jan 1, 1994·Scandinavian Journal of Gastroenterology. Supplement·D YsebaertE Eyskens
Jan 1, 1996·Digestion·C BassiP Pederzoli
Oct 1, 1996·The Surgical Clinics of North America·M M Meguid, A C Campos
Oct 1, 1996·The Surgical Clinics of North America·R Rolandelli, J J Roslyn
Oct 1, 1996·American Journal of Surgery·P MartineauR Denis

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Citations

Mar 21, 2008·Gastroentérologie Clinique Et Biologique·Gaëlle MontmayeurXavier Durando
May 19, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Philippe LévyPhilippe Ruszniewski
May 2, 2013·The Cochrane Database of Systematic Reviews·Kurinchi Selvan GurusamyBrian R Davidson
Jun 25, 2003·Annales de chirurgie·K Slim, J Le Borgne

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