Evaluation of large volume-difficult matrix introduction-gas chromatography-time of flight-mass spectrometry (LV-DMI-GC-TOF-MS) for the determination of pesticides in fruit-based baby foods

Food Additives and Contaminants
Katan PatelBrendan J Keely

Abstract

The European Union Baby Food Directive (1999/39/EC), which came into force on 1 July 2002, set legal maximum residue levels at 0.01 mg kg(-1) for all pesticides in baby foods. The combination of large volume-difficult matrix introduction (LV-DMI) with gas chromatography-time of flight-mass spectrometry (GC-TOF-MS), described herein, provides the analyst with a simple but rapid alternative GC-MS technique for the multiresidue analysis of pesticides in fruit-based baby foods. Samples were extracted with ethyl acetate in the presence of Na2SO4 and NaHCO3 and the crude extracts were analysed directly using LV-DMI-GC-TOF-MS. The best overall results (98 pesticides quantified satisfactorily at a spiking level of 0.01 mg kg(-1)) were obtained by analysis of concentrated extracts (2.5 g crop ml(-1)) using a 30-m column, with a chromatographic run time of 25 min. A good signal-to-noise ratio was obtained at the lowest calibrated level (0.0125 microg ml(-1)), with excellent linearity achieved over the range 0.0125-0.25 microg ml(-1) (equivalent to 0.005-0.1 mg kg(-1)). Average recoveries for the analysis of five replicate determinations at a spiking level of 0.01 mg kg(-1) were between 79 and 114% with relative standard derivations gener...Continue Reading

References

Jun 24, 2000·Journal of Chromatography. a·M M van DeurseC A Cramers
Jan 10, 2003·Food Additives and Contaminants·P J Cressey, R W Vannoort

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Citations

May 3, 2007·Biomedical Chromatography : BMC·Leah N Williamson, Michael G Bartlett
Apr 2, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Corina PfeiferRobert Reinhardt
Jun 7, 2006·Mass Spectrometry Reviews·Lutz AlderBärbel Vieth
Jan 27, 2005·Journal of Mass Spectrometry : JMS

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