Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection

PloS One
Etsuko KajimotoTetsuji Naka

Abstract

This study aimed to determine the association between umbilical cord leucine-rich alpha-2 glycoprotein (LRG) and fetal infection and investigate the underlying mechanism of LRG elevation in fetuses. We retrospectively reviewed the medical records of patients who delivered at Osaka University Hospital between 2012 and 2017 and selected those with histologically confirmed chorioamnionitis (CAM), which is a common pregnancy complication that may cause neonatal infection. The participants were divided into two groups: CAM with fetal infection (CAM-f[+] group, n = 14) and CAM without fetal infection (CAM-f[-] group, n = 31). Fetal infection was defined by the histological evidence of funisitis. We also selected 50 cases without clinical signs of CAM to serve as the control. LRG concentrations in sera obtained from the umbilical cord were unaffected by gestational age at delivery, neonatal birth weight, nor the presence of noninfectious obstetric complications (all, p > 0.05). Meanwhile, the LRG levels (median, Interquartile range [IQR]) were significantly higher in the CAM-f(+) group (10.37 [5.21-13.7] μg/ml) than in the CAM-f(-) (3.61 [2.71-4.65] μg/ml) or control group (3.39 [2.81-3.93] μg/ml; p < 0.01). The area under the receive...Continue Reading

References

Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
May 29, 1999·Lancet·S Mehr, L Doyle
Aug 5, 2000·Journal of Reproductive Immunology·F SajiT Kimura
Sep 16, 2000·JAMA : the Journal of the American Medical Association·Y W Wu, J M Colford
Aug 14, 2001·American Journal of Respiratory and Critical Care Medicine·S HarbarthUNKNOWN Geneva Sepsis Network
Nov 25, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·B H YoonJ K Jun
Jan 31, 2004·Clinical Chemistry·Claudio ChiesaLucia Pacifico
Apr 23, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·P C Ng
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Liliana SimonJacques Lacroix
Dec 24, 2005·Archives of Disease in Childhood. Fetal and Neonatal Edition·N JoramC Gras-Le Guen
Jan 5, 2008·Developmental Medicine and Child Neurology·Heidi K BlumeThomas D Koepsell
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teppei NishikawaKazuyuki Yoshizaki
Mar 26, 2009·American Journal of Obstetrics and Gynecology·Juan M GonzalezMichal A Elovitz
Mar 28, 2009·Biochemical and Biophysical Research Communications·Ryoichi ShiraiSeiji Inoue
Dec 3, 2009·The Pediatric Infectious Disease Journal·Michael Cohen-WolkowiezP Brian Smith
May 6, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Miğraci TosunErdal Malatyalioğlu
Oct 12, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·M GantertB W Kramer
Oct 16, 2010·International Journal of Cancer. Journal International Du Cancer·Kota IwahoriTetsuji Naka
Dec 4, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Nora HoferBernhard Resch
Feb 23, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Claudio ChiesaMario De Curtis
Mar 23, 2011·Reproductive Sciences·Irina BurdMichal A Elovitz
Apr 27, 2011·Pediatrics·Barbara J StollUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Jun 10, 2011·The Pediatric Infectious Disease Journal·Emily J WestonStephanie J Schrag
Mar 1, 2012·Inflammatory Bowel Diseases·Satoshi SeradaTetsuji Naka
May 11, 2012·World Journal of Pediatrics : WJP·Ying Fan, Jia-Lin Yu
May 30, 2012·The Journal of Obstetrics and Gynaecology Research·Maryam KashanianSaeedesadat Bathaee
Jun 13, 2012·Journal of Korean Medical Science·Sung Youn LeeKyoung Un Park
Jun 28, 2013·The Journal of Obstetrics and Gynaecology Research·Abdullah KaraerSenem Arda Duz
May 3, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·M H Malloy
Dec 19, 2014·Scandinavian Journal of Infectious Diseases·Sofie Sommer HedegaardAnne-Mette Hvas
Jan 21, 2015·American Journal of Reproductive Immunology : AJRI·Satoshi YonedaShigeru Saito
Sep 10, 2015·American Journal of Perinatology·David BraunDarios Getahun
Oct 3, 2015·American Journal of Obstetrics and Gynecology·Chong Jai KimYeon Mee Kim
Jul 28, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Taiki Samejima, Kimihiro Takechi
Jul 28, 2016·World Journal of Clinical Cases·Salvatore Giovanni VitaleDiego Rossetti
Nov 3, 2016·Journal of Crohn's & Colitis·Shinichiro ShinzakiTetsuji Naka
Jun 15, 2018·Hypertension·Mark A BrownUNKNOWN International Society for the Study of Hypertension in Pregnancy (ISSHP)
Jul 28, 2019·American Journal of Obstetrics and Gynecology·Mamoru KakudaTadashi Kimura
Feb 27, 2020·Scientific Reports·Minoru FujimotoTetsuji Naka

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection
enzyme-linked immunosorbent assay
electrophoresis
PCR
SGA

Software Mentioned

Excel Statistics
JMP®

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.