Evaluation of leuprolide acetate and gonadotropins versus clomiphene citrate and gonadotropins for in vitro fertilization or gamete intrafallopian transfer

Fertility and Sterility
A FerrierA S Berkeley

Abstract

A prospective randomized trial was conducted to compare the efficiency of two ovarian stimulation protocols for in vitro fertilization-embryo transfer or gamete intrafallopian transfer. Protocol 1 consisted of clomiphene citrate and human menopausal gonadotropin (hMG) with 55 cycles of 42 patients being evaluated. Protocol 2 had 38 cycles of 34 patients receiving a gonadotropin-releasing hormone agonist (GnRH-a) and hMG. The incidence of a spontaneous luteinizing hormone surge was 38.2% in protocol 1 and 0% in protocol 2. Both protocols had a similar cancellation rate. The total clinical pregnancy rates per oocyte retrieval for patients receiving protocol 1 and protocol 2 were 19.5% and 10.3%, respectively. The difference was not statistically significant. Therefore, as first-line ovulation induction agents, it cannot be concluded that either protocol demonstrates a clear superiority over the other and further trials of the GnRH-a/hMG combination are indicated.

Citations

Dec 1, 1994·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Z Ben-RafaelD Feldberg
Nov 1, 1993·British Journal of Obstetrics and Gynaecology·P VandekerckhoveT W Harada
Dec 22, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D GrochowskiM Szamatowicz
May 1, 1993·Journal of Assisted Reproduction and Genetics·D C LoutradisD Aravantinos
Jan 1, 1995·Journal of Assisted Reproduction and Genetics·C A BenadivaZ Rosenwaks
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Ahmed GibreelSiladitya Bhattacharya
Sep 24, 2005·The Journal of Obstetrics and Gynaecology Research·Areepan SophonsritsukAram Rojanasakul

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