Evaluation of lipid-coated microbubbles as a delivery vehicle for Taxol in brain tumor therapy

Neurosurgery
S Y HoR H Simon

Abstract

This work evaluates the potential of lipid-coated microbubbles (LCM) as a delivery vehicle for lipid-soluble antineoplastic agents. We have shown, in rats, the selective affinity of intravenously administered LCM for tumor cells. They are internalized by the tumor cells both in vitro and in vivo. The specificity of LCM for tumors and subsequent incorporation into the cytoplasm could significantly reduce the systemic effects of an agent incorporated into the bubbles, such as Taxol. The in vitro methods were as follows. C6 cells (10(5) cells) were treated with Taxol-LCM (6 micrograms/ml), Taxol-Cremophore (6 micrograms/ml), or LCM alone for 8 or 24 hours. Cell death was determined by staining the cells with nuclear staining. Abnormalities of microtubule structures were ascertained by confocal microscopy. The in vivo methods were as follows. Two rat tumor models (C6 and 9L) were used. Rats were treated with single bolus injections or with repetitive (two or three) treatment courses, with respective control animals. Each course consisted of one daily tail vein injection for 5 consecutive days and then 2 days of rest. When compared with either a saline control group or a group receiving Taxol in an oil vehicle, Taxol-LCM reduced tum...Continue Reading

References

Jul 11, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R B WeissB Leyland-Jones
Aug 1, 1990·Journal of the National Cancer Institute·E K RowinskyR C Donehower
Dec 1, 1990·Investigative Radiology·R H SimonS G Hamilton
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M De BrabanderJ De Mey
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M A JordanL Wilson
Mar 1, 1993·Investigative Radiology·J S D'ArrigoR H Simon
Oct 1, 1995·Journal of Neuro-oncology·E BarbareseR H Simon
Aug 1, 1991·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·J S D'ArrigoS Y Ho

❮ Previous
Next ❯

Citations

Dec 4, 2002·Japanese Journal of Cancer Research : Gann·Insook HanYoun Soo Sohn
Sep 28, 2002·Journal of Magnetic Resonance Imaging : JMRI·Paul A Dayton, Katherine W Ferrara
Jan 6, 2004·Journal of Biomedical Materials Research. Part a·T RizkP Menei
Dec 2, 2004·The British Journal of Radiology·H-D Liang, M J K Blomley
Mar 21, 2001·Biotechnology & Genetic Engineering Reviews·D J Durzan
Sep 27, 2008·Expert Opinion on Drug Delivery·Christian R MayerRaffi Bekeredjian
Dec 15, 2020·American Journal of Alzheimer's Disease and Other Dementias·Joseph S D'Arrigo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.