Evaluation of lipid-stabilised tripropionin nanodroplets as a delivery route for combretastatin A4

International Journal of Pharmaceutics
Victoria MicoStephen D Evans

Abstract

Lipid-based nanoemulsions are a cheap and elegant route for improving the delivery of hydrophobic drugs. Easy and quick to prepare, nanoemulsions have promise for the delivery of different therapeutic agents. Although multiple studies have investigated the effects of the oil and preparation conditions on the size of the nanoemulsion nanodroplets for food applications, analogous studies for nanoemulsions for therapeutic applications are limited. Here we present a study on the production of lipid-stabilised oil nanodroplets (LONDs) towards medical applications. A number of biocompatible oils were used to form LONDs with phospholipid coatings, and among these, squalane and tripropionin were chosen as model oils for subsequent studies. LONDs were formed by high pressure homogenisation, and their size was found to decrease with increasing production pressure. When produced at 175MPa, all LONDs samples exhibited sizes between 100 and 300nm, with polydispersity index PI between 0.1 and 0.3. The LONDs were stable for over six weeks, at 4°C, and also under physiological conditions, showing modest changes in size (<10%). The hydrophobic drug combretastatin A4 (CA4) was encapsulated in tripropionin LONDs with an efficiency of approximatel...Continue Reading

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Citations

Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gökçe Şeker KaratoprakEduardo Sobarzo-Sánchez
Jun 17, 2020·Chemical Society Reviews·Saeid KargozarMasoud Mozafari
Apr 25, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Antonia CharalambousP Louise Coletta
Aug 4, 2021·The Review of Scientific Instruments·Radwa H Abou-SalehStephen D Evans
Mar 23, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Radwa H Abou-SalehNeil H Thomson
Feb 12, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Lingling KongTuomas P J Knowles

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