Evaluation of liposome-water partitioning for predicting bioaccumulation potential of hydrophobic organic chemicals

Environmental Science & Technology
Stephan A Van der Heijden, Michiel T O Jonker

Abstract

Considering the importance of bioaccumulation factors (BAFs) in risk assessment of chemicals and the ethical issues and complexity of the determination of these factors in standard tests with living organisms, there is a need for alternative approaches for predicting bioaccumulation. In this study, liposome-water partitioning coefficients as determined by using solid-phase microextraction (SPME) were evaluated for the cause of assessing bioaccumulation potential of hydrophobic organic chemicals (HOCs). To this end, the SPME method was mapped (in terms of mass balance, mode of spiking, kinetics, and reproducibility) and validated against literature data. Furthermore, the robustness of liposomes as partitioning phase was investigated (in terms of chemical loading, and pH and ionic strength of the medium), and finally liposome-water partition coefficients (K(lipw)) determined for polycyclic aromatic hydrocarbons (PAHs; 4.5 < logK(ow) < 7.2) were compared with literature BAF values for several aquatic species. The results indicated that (i) SPME is a valid, fast, and reproducible method for measuring K(lipw) values; (ii) liposomes provide a very robust partitioning phase; and (iii) K(lipw) values agreed very well with literature PA...Continue Reading

References

Sep 1, 1993·Chemistry and Physics of Lipids·M Grit, D J Crommelin
Jun 15, 2005·Environmental Science & Technology·Thomas L ter LaakJoop L M Hermens
Mar 31, 2006·Environmental Science & Technology·Sibylle M Kaiser, Beate I Escher
Aug 19, 2006·Environmental Toxicology and Chemistry·Jung-Hwan KwonLynn E Katz
Jun 26, 2007·Biophysical Journal·Georg PabstPeter Laggner
Nov 30, 2007·Environmental Science & Technology·Michiel T O Jonker, Stephan A Van der Heijden
Jan 16, 2008·The Journal of Physical Chemistry. B·Arnau CordomíJuan J Perez
Mar 20, 2008·Environmental Toxicology and Chemistry·Jon A ArnotMark Bonnell
Jul 17, 2009·Environmental Science & Technology·Barry Muijs, Michiel T O Jonker
May 1, 1982·Environmental Science & Technology·D Mackay

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Citations

Jun 5, 2013·Ecotoxicology and Environmental Safety·So-Young LeeJung-Hwan Kwon
Mar 23, 2011·Environmental Science & Technology·Barry Muijs, Michiel T O Jonker
Jun 16, 2011·Environmental Science & Technology·Satoshi EndoKai-Uwe Goss
Nov 8, 2011·Environmental Science & Technology·Stephan A van der Heijden, Michiel T O Jonker
Mar 9, 2012·Environmental Science & Technology·A Patricia TcaciucPhilip M Gschwend
Jan 29, 2016·Chemosphere·Anastasiia GoliusJerzy Leszczynski
Mar 1, 2013·Journal of Computational Chemistry·Sven JakobtorweihenIrina Smirnova
Apr 30, 2013·Environmental Toxicology and Chemistry·Dave T F Kuo, Dominic M Di Toro
Apr 3, 2016·Journal of Hazardous Materials·Hyun-Joong KangJung-Hwan Kwon
Nov 18, 2015·Journal of Chemical Theory and Computation·Samuel Genheden, Jonathan W Essex
Jul 28, 2015·Physical Chemistry Chemical Physics : PCCP·Helmut I Padilla-ChavarríaAndre S Pimentel
Jul 24, 2020·Environmental Health Perspectives·Beate I EscherFabian C Fischer
Sep 10, 2020·International Journal of Environmental Research and Public Health·So-Young Lee, Jung-Hwan Kwon
Apr 11, 2018·Environmental Health and Toxicology·Ji-Yeon RohJung-Hwan Kwon
Jun 24, 2019·Archives of Toxicology·Luise HennebergerBeate I Escher
Aug 8, 2020·The Science of the Total Environment·Jakub MaculewiczJoanna Dołżonek
Jul 27, 2021·Biophysical Journal·Katelyn M DuncanRobert A Walker
Dec 20, 2019·Environmental Science & Technology·Luise HennebergerBeate I Escher
Sep 9, 2014·Journal of Chemical Theory and Computation·Markéta PaloncýováMichal Otyepka
Sep 3, 2021·Journal of Chemical Theory and Computation·Thomas D PotterMark A Miller

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