Evaluation of live and inactivated influenza A virus vaccines in a mouse model

The Journal of Infectious Diseases
D ArmerdingE Liehl

Abstract

Induction of cross-protective immunity against serologically distinct subtypes of influenza A virus in mice was examined in an attempt to correlate cross-protection with heterotypic lymphocyte responses. Live and inactivated virus vaccines protected against the homologous subtype, but only whole virus protected against heterologous subtypes. Live virus vaccines provided better cross-protection than inactivated virus vaccines. A weak defense against heterotypic challenge generated by live H0N1 virus could be boosted by cross-stimulation with whole H3N2 virus and by restimulation with pathogenic H0N1 virus. Heterotypic protection persisted for at least five months. Live viruses induced cross-reactive cytotoxic T cells in normal mice. However, cross-stimulation with heterologous virus was required to generate secondary cytotoxicity. Cross-reactive B lymphocytes were evident after inoculation with whole virus.

Citations

Jan 1, 1982·Medical Microbiology and Immunology·D ArmerdingE Liehl
Nov 23, 2007·Journal of Virology·Fu-Shi QuanSang-Moo Kang
Nov 23, 2011·Respiratory Research·Chad J RoySrinivas S Rao
Jun 15, 2005·Scandinavian Journal of Immunology·C ColecloughJ L Hurwitz
May 7, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yeu-Chun KimMark R Prausnitz
Dec 19, 2002·International Reviews of Immunology·Carolina B LópezAna Fernandez-Sesma
Jul 31, 2008·Expert Review of Vaccines·Jan Willem van der LaanJohn Oxford
Oct 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura HaynesStephen T Smiley

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