Evaluation of longitudinal steroid profiles from male football players in UEFA competitions between 2008 and 2013

Drug Testing and Analysis
Norbert BaumeMartial Saugy

Abstract

Testosterone and related compounds are the most recurrent doping substances. The steroid profile, consisting of the quantification of testosterone and its metabolites, has been described as the most significant biomarker to detect doping with pseudo-endogenous anabolic steroids. The steroidal module of the Athlete Biological Passport (ABP) was launched by the World Anti-Doping Agency (WADA) in 2014. To assess the value of introducing the module to its anti-doping programme, the Union of European Football Associations (UEFA) decided to analyze retrospectively the steroid profile data of 4195 urine samples, collected from 879 male football players and analyzed in 12 WADA-accredited laboratories between 2008 and mid-2013. This study focused on the evaluation of T/E ratios. The coefficient of variation (CV) and the adaptive model were the two statistical models used to study the longitudinal follow-up. A CV of 46% was determined to be the maximal natural intra-individual variation of the T/E when the sequence consisted of single data points analyzed in different laboratories. The adaptive model showed some profiles with an atypical T/E sequence and also enabled an estimate of the prevalence of external factors impacting the T/E seq...Continue Reading

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Citations

Nov 26, 2016·Drug Testing and Analysis·Mario ThevisWilhelm Schänzer
Jan 20, 2018·Drug Testing and Analysis·Jenny MullenLena Ekström
Oct 10, 2018·Current Sports Medicine Reports·Perikles SimonYannis P Pitsiladis
Feb 14, 2020·Drug Testing and Analysis·Jenny MullenJenny J Schulze
Mar 8, 2017·Drug Testing and Analysis·Adam T Cawley, John Keledjian

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