Evaluation of lung cancer by enhanced dual-energy CT: association between three-dimensional iodine concentration and tumour differentiation

The British Journal of Radiology
Shingo IwanoShinji Naganawa

Abstract

To investigate the correlation between iodine concentration of dual-energy CT (DECT) and histopathology of surgically resected primary lung cancers. We reviewed the medical records, post-operative pathological records and pre-operative DECT images of patients who underwent surgical lung resection for primary lung cancer. After injection of iodinated contrast media, arterial and delayed phases were scanned using 140- and 80-kV tube voltages. Three-dimensional iodine concentration (iodine volume) of primary tumours was calculated using lung nodule application software. A total of 60 patients (37 males and 23 females; age range, 39-84 years; mean age, 69 years) with 62 lung cancers were analysed. The resected tumours were histopathologically classified into well-differentiated (G1; n = 20), moderately differentiated (G2; n = 29), poorly differentiated (G3; n = 9) and undifferentiated (G4; n = 4) groups by degree of tumour differentiation (DTD). The mean ± standard deviation of iodine volume at the delayed phase was 59.6 ± 18.6 HU in G1 tumours, 46.5 ± 11.3 HU in G2 tumours, 34.3 ± 15.0 HU in G3 tumours and 28.8 ± 6.4 HU in G4 tumours; significant differences were observed between groups (p < 0.001). Univariate logistic regression ...Continue Reading

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Citations

Sep 27, 2016·European Journal of Radiology·Víctor González-PérezMiguel Arrarás
Aug 8, 2018·AJR. American Journal of Roentgenology·Hyungjin KimJin Mo Goo
Dec 19, 2018·Head & Neck·Do Hyung LeeKyung-Sook Yang
Jan 16, 2019·Radiology·Simon LennartzThorsten Persigehl
Jan 12, 2020·La Radiologia medica·Giuseppe CiceroSilvio Mazziotti
Jul 28, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Hironori ShimamotoShinji Naganawa
Jan 12, 2021·Journal of Applied Clinical Medical Physics·Wen-Hui HuangChing-Ching Yang
Jan 28, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Simon LennartzThorsten Persigehl
Jan 9, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Shingo IwanoShinji Naganawa
Nov 17, 2021·Radiology·David J Murphy, David T Ryan

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