Evaluation of lung tolerance of ethanol, propylene glycol, and sorbitan monooleate as solvents in medical aerosols

Journal of Aerosol Medicine and Pulmonary Drug Delivery
Jérôme MontharuMichèle de Monte

Abstract

Aerosol therapy is an expanding technique allowing administration of drugs acting locally in the bronchial tree and lungs or acting systemically after absorption through the respiratory tract. However, the choice of solvents and adjuvants is a critical step in the formulation process of new drugs. Pulmonary tolerance of ethanol, propylene glycol and sorbitan ester was evaluated in a rat model of intratracheal administration using a Microsprayer in a 4-day toxicity study. Four groups of Sprague-Dawley rats (11 rats per group, n = 44) have received, on 4 consecutive days 150 microL of solutions containing the solvents, by intratracheal route using a IA-1B-2 inches-Microsprayer (PennCentury, Philadelphia, PA). Once a day, the rats received deionized water (control) or ethanol 10% or propylene glycol 30% or sorbitan monooleate 10%. All rats were sacrificed 24 h after the fourth administration. Biochemical analysis on bronchoalveolar lavage (BAL) fluid was performed on seven rats per group. The respiratory tract of the remaining four rats/group was examined histologically. Biochemistry and histopathology findings demonstrated that under the conditions tested, deionized water, 10% ethanol, and 30% propylene glycol were tolerated in a...Continue Reading

References

Jul 1, 1987·Early Human Development·G S GauM A Mobberley
Dec 1, 1981·Environmental Health Perspectives·Y Alarie
Aug 10, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·L Vecellio NoneP Diot
Sep 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·W S ChoiA M Klibanov
Oct 22, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Suzanne E BeckWilliam B Guggino
Jun 26, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Abhishek GuptaPaul B Myrdal
Oct 1, 1963·Journal of Pharmaceutical Sciences·A J SPIEGEL, M M NOSEWORTHY
Sep 24, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Birgit KittelUNKNOWN NACAD Group
Jun 22, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Frédéric GagnadouxEtienne Lemarié
Jul 16, 2005·Inhalation Toxicology·Robert S ScottGerald L Kennedy
Sep 26, 2006·Advanced Drug Delivery Reviews·T E Corcoran
Dec 27, 2007·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Tao WangNancy Turner

❮ Previous
Next ❯

Citations

Mar 18, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Thiago C CarvalhoJason T McConville
Apr 12, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ralph NivenHoward Raff
Jan 6, 2015·Expert Opinion on Drug Delivery·Renaud RespaudNathalie Heuzé-Vourc'h
Feb 1, 2012·The Nursing Clinics of North America·Carol A RikerEllen J Hahn
Jun 8, 2012·Indoor Air·T SchrippT Salthammer
May 23, 2012·International Journal of Pharmaceutics·A GuillonM de Monte
Jun 3, 2011·International Journal of Toxicology·Sheela SharmaVernon E Steele
Jun 29, 2017·European Journal of Mass Spectrometry·Cecilia SalaEnrico Davoli
Nov 23, 2018·The European Respiratory Journal·Robert BalsFrancesco Blasi
Apr 18, 2019·AAPS PharmSciTech·Usir S YounisPaul B Myrdal
Aug 24, 2021·Applied Microbiology and Biotechnology·Hilal Ahmad ParrayRajesh Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Molecular Therapy : the Journal of the American Society of Gene Therapy
Suzanne E BeckWilliam B Guggino
International Journal of Pharmaceutics
Feng QianRonald L Smith
Journal of Controlled Release : Official Journal of the Controlled Release Society
Luis DellamaryAdrian Bot
Journal of Biomedical Materials Research. Part a
Y C HuangC H Chiang
© 2021 Meta ULC. All rights reserved