Evaluation of lymph node metastases in gastric cancer using magnetic resonance imaging with ultrasmall superparamagnetic iron oxide (USPIO): diagnostic performance in post-contrast images using new diagnostic criteria.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Takaya TokuharaIsamu Narabayashi

Abstract

We assessed the value of magnetic resonance imaging (MRI), using ultrasmall superparamagnetic iron oxide (USPIO) with new diagnostic criteria, in the evaluation of regional lymph node metastases in gastric cancer. Thirty-one patients with gastric cancer were enrolled. 1000 lymph nodes were dissected during surgery, and of these, 519 nodes (51.9%) were identified by currently used MRI imaging analysis. We evaluated lymph nodes on USPIO-post-contrast T2*-weighted images using the following two criteria: (1) we diagnosed the nodes on T2*-weighted images according to conventional criteria, where a node having an overall low signal intensity (pattern A) was nonmetastatic, while a node having partial (pattern B) or overall (pattern C) high signal intensity was metastatic; (2) we subdivided pattern B nodes on T1-weighted images using the new criteria, in which a node for which the high-intensity area on T2*-weighted images was not defined as adipose tissue on T1-weighted images (pattern B1) was metastatic, while a node for which the high-intensity area was defined as adipose tissue (pattern B2) was nonmetastatic. (1) The results using the conventional criteria were 96.2% sensitivity, 92.5% specificity, 76.3% positive predictive value ...Continue Reading

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Citations

May 2, 2014·World Journal of Gastroenterology : WJG·Joon-Il ChoiJeong Min Lee
Mar 16, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ciprian CatanaBruce R Rosen
Dec 4, 2010·Pediatric Radiology·Carola Heneweer, Jan Grimm
Sep 16, 2014·Expert Review of Gastroenterology & Hepatology·Michael Bau Mortensen
Jun 1, 2012·Expert Review of Gastroenterology & Hepatology·Paul D SykesChristopher M Halloran
Jun 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Jing LeiZheng Yu Jin
Feb 23, 2019·The British Journal of Radiology·Alicia S BorggreveJelle P Ruurda
Jun 16, 2018·Frontiers in Surgery·Chrysovalantis Vergadis, Dimitrios Schizas

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