Evaluation of lymph node perfusion using continuous mode harmonic ultrasonography with a second-generation contrast agent

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
Leopoldo RubaltelliCarlo Riccardo Rossi

Abstract

To evaluate the contribution of continuous mode contrast-enhanced harmonic ultrasonography (CE-HUS) with a second-generation contrast agent to the characterization of superficial lymphadenopathies with respect to conventional ultrasonographic techniques (B-mode and power Doppler). Fifty-six lymph nodes from 45 patients were studied both by conventional techniques and by CE-HUS. The dimensions, intranodal architecture, margins, and location of vessels were evaluated. Subsequently, all the lymph nodes were examined by CE-HUS, and enhancement of echogenicity was evaluated. The diagnoses obtained by means of fine-needle aspiration cytologic examination, surgical biopsy, or both were compared with those obtained by ultrasonography. Of the lymph nodes examined, 30 were benign and 26 were malignant (18 metastases and 8 non-Hodgkin lymphomas). The study using CE-HUS showed intense homogeneous enhancement in 28 of 30 reactive lymph nodes; perfusion defects in 17, of which 15 were neoplastic and 2 were inflammatory; intense but inhomogeneous speckled enhancement in the early arterial phase in 5 cases of lymphoma; and, last, scarce or absent intranodal enhancement in 4 metastases. The specificity, sensitivity, and accuracy of conventional...Continue Reading

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Citations

Mar 14, 2007·European Radiology·Emilio Quaia
Aug 7, 2008·Journal of Veterinary Internal Medicine·S OhlerthB Kaser-Hotz
Apr 5, 2011·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Barry B GoldbergScott A Waldman
Mar 23, 2007·AJR. American Journal of Roentgenology·Leopoldo RubaltelliRoberto Stramare
Apr 30, 2010·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ming YuXiao-Dong Zhou
Dec 24, 2010·AJR. American Journal of Roentgenology·Leopoldo RubaltelliRoberto Stramare
May 20, 2008·Seminars in Cutaneous Medicine and Surgery·Monika-Hildegard Schmid-Wendtner, Dorothee Dill-Müller
Jan 23, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
Jul 16, 2016·Clinical and Experimental Otorhinolaryngology·Zheng CuiZhaoxin Ma
Aug 6, 2020·Praxis·Jan Tuma
Apr 3, 2008·American Journal of Veterinary Research·Daniele Della SantaJohann Lang
Jan 22, 2008·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Ying HuangFan-Hua Xu
Jul 21, 2016·The Journal of Obstetrics and Gynaecology Research·Siyue MaoPeihong Wu
Sep 7, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Shanshan YinKun Yan
Jan 4, 2019·Biomedical Engineering Letters·Haemin Kim, Jin Ho Chang
Jul 12, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Qiu-Li CuiKun Yan
May 28, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Tomoyuki OhtaKumiko Kato
Apr 30, 2010·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Orlando CatalanoAdolfo Gallipoli D'Errico
Apr 9, 2021·Pediatric Radiology·Maciej PiskunowiczDean Y Huang
May 6, 2021·Journal of Clinical Imaging Science·Rita TavarozziAnna Lombardi

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