Evaluation of magnetic resonance imaging and clinical outcome after tissue-engineered cartilage implantation: prospective 6-year follow-up study.

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
Kobun TakazawaMitsuo Ochi

Abstract

Autologous chondrocyte implantation (ACI) is an important procedure when repairing cartilage defects of the knee. We previously reported several basic studies on tissue-engineered cartilage, and conducted a multicenter clinical study in 2009. In this clinical study, we evaluated the patients' clinical scores and MRI findings before and after tissue-engineered cartilage implantation, and compared the data obtained at 1 year and approximately 6 years post-implantation. Fourteen patients who underwent implantation of tissue-engineered cartilage to repair cartilage defects of the knee were evaluated. Tissue-engineered cartilage was produced by culturing autologous chondrocytes three dimensionally in atelocollagen gel. The patients were evaluated clinically using the Lysholm score, and the original knee-function score at pre-implantation and at 1 year and approximately 6 years post-implantation. MRI scans were obtained at the same observation periods. A modified magnetic resonance observation of cartilage repair tissue (MOCART) system was used to quantify clinical efficacy based on the MRI findings. In approximately 6 years of follow-up, none of the 14 patients reported any subjective symptoms of concern. The mean Lysholm score and ...Continue Reading

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Citations

May 15, 2013·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Nobuo AdachiJunji Iwasa
Dec 3, 2014·Magnetic Resonance Imaging Clinics of North America·Michael C ForneyCarl S Winalski
Jan 8, 2016·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Goki KameiMitsuo Ochi
Nov 30, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·James H P HuiUNKNOWN Asian Cartilage Society
Mar 19, 2013·Clinical Biomechanics·Goki KameiMuhammad Andry Usman
May 5, 2017·Tissue Engineering. Part C, Methods·Seiju HayashiMitsuo Ochi
Jan 4, 2017·Sports Medicine and Arthroscopy Review·Luca AndrioloElizaveta Kon
Mar 4, 2020·The American Journal of Sports Medicine·Kyoung-Ho YoonSang-Gyun Kim
Mar 20, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Naosuke KameiTakaaki Kobayashi
May 15, 2019·The American Journal of Sports Medicine·Kristofer J JonesPeter D Fabricant
Nov 12, 2018·ACS Biomaterials Science & Engineering·Redouan MahouMichael V Sefton
Aug 27, 2021·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·José Carlos De Lucas VillarrubiaAlberto Panadero Tapia

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Methods Mentioned

BETA
delamination

Software Mentioned

MOCART

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