Evaluation of malnutrition with blood ghrelin and fecal elastase levels in acute decompensated heart failure patients

Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
Mustafa ÖzcanTufan Tükek

Abstract

Exocrine pancreatic dysfunction may contribute to malnutrition and lack of appetite in the advanced stages of heart failure. Nutritional assessment was carried out on patients diagnosed with mild or moderate/severe heart failure. Fecal elastase levels are an indicator of pancreatic exocrine function and ghrelin is an appetite hormone which is also investigated for its contribution to malnutrition. This is an observational study. 52 patients (32 males, 20 females) aged over eighteen years and hospitalized for acute decompensated heart failure (ADHF) were included in the study. They were compared with 31 people (16 male, 15 female) of the same age as Control Group (C). Patients in New York Heart Association (NYHA) stages 1 and 2 were grouped as mild (miADHF), while those in NYHA stages 3 and 4 were grouped as moderate/severe ADHF (seADHF). Fecal and blood samples were taken at admission. In ADHF patients, exocrine pancreatic functions and their relationship with malnutrition were evaluated. Statistical analyses were performed using Tukey's test, the independent-sample t-test, the Kruskal-Wallis test, the Mann-Whitney U-test, the chi-square test and Pearson's bivariate correlation analysis. Significantly decreased fecal elastase l...Continue Reading

Citations

Aug 11, 2015·Journal of Pharmaceutical and Biomedical Analysis·Gülden Yeşiller, Mustafa Kemal Sezgintürk
May 18, 2016·Advances in Nutrition·Nádia Cristina Fávaro-MoreiraJoke Duyck
Dec 6, 2019·World Journal of Gastroenterology : WJG·Sara NikolicMiroslav Vujasinovic

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