Evaluation of Markers of Inflammation and Oxidative Stress in COPD Patients with or without Cardiovascular Comorbidities

Heart, Lung & Circulation
Marcin KaźmierczakAdam Antczak

Abstract

Although both chronic obstructive pulmonary disease (COPD) and cardiovascular diseases (CVD) are characterised by chronic, systemic inflammation, their reciprocal interactions are poorly understood. The purpose of this study was to determine the concentrations of both inflammatory and oxidative stress biomarkers in the serum and exhaled breath condensate (EBC) of COPD patients, either with coexisting CVD or without cardio-vascular comorbidities. Twenty-four COPD patients with CVD were allocated to group A, 20 COPD patients without CVD were assigned to group B and 16 healthy patients were included as a control. A medical history and physical examination were performed, and the following were measured: serum CRP concentration, glucose level, uraemic acid level and lipid profile. In addition 8-isoprostane, LTB4 and IL-8 concentrations were measured both in serum and EBC. Spirometry, six-minute walk test and echocardiography were performed in all subjects. EBC concentrations of 8-isoprostane and LTB4, and serum levels of CRP, 8-soprostane, LTB4, IL-8 were significantly higher in COPD patients than in healthy controls. COPD patients with CVD were not found to have higher concentrations of the assessed markers than those without CVD,...Continue Reading

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Citations

Dec 17, 2015·Heart, Lung & Circulation·Salvatore Pepe
Apr 17, 2019·Journal of Clinical Pharmacy and Therapeutics·Juan GuoJuan Feng
Sep 18, 2020·Biomarkers in Medicine·Somayeh KazeminasabMaryam Khoubnasabjafari
Jul 4, 2020·Environmental Health : a Global Access Science Source·Limin CaoWeihong Chen
May 25, 2016·Clinical Science·Victoria AustinRoss Vlahos
Oct 26, 2018·The Korean Journal of Internal Medicine·Sule Tas GulenFisun Karadag
Aug 30, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·B I GeltserYu V Zayats
Jun 9, 2020·Oxidative Medicine and Cellular Longevity·Elisabetta ZinelluPietro Pirina
Apr 26, 2019·Bulletin of Experimental Biology and Medicine·V N Kotel'nikovO V Topil'skaya

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