Evaluation of matricellular proteins in systemic and local immune response to Mycobacterium tuberculosis infection

Microbiology and Immunology
Fakhrial Mirwan HasibuanToshio Hattori

Abstract

Matricellular proteins such as osteopontin (OPN), galectin-9 (Gal-9), and tenascin-C (TN-C) are expressed not only under normal physiological conditions, but also during infection, inflammation and tumorigenesis. Plasma concentrations of matricellular proteins were studied to determine their diagnostic value as potential markers of tuberculosis (TB) activity. It was found that concentrations of OPN and TN-C were higher in patients with active TB than in healthy controls and individuals with latent infection. Moreover, LTBI patients had higher concentrations of OPN than did healthy controls. Gal-9 concentrations did not differ significantly between groups. Concentrations of matricellular proteins were higher in pleural fluid than in the plasma of patients with TB. Expression of matricellular proteins was also investigated in TB granulomas and other granulomatous diseases. Positive OPN and Gal-9 staining was observed in TB and sarcoidosis granulomas, but not in Crohn disease granulomas. The fibrotic ring around granulomas stained positive for TN-C in TB and sarcoidosis, but not in Crohn disease. Of the three matricellular proteins studied, OPN and TN-C may serve as reliable plasma markers for monitoring TB activity, whereas Gal-9...Continue Reading

References

Feb 28, 1997·The Journal of Biological Chemistry·J Wada, Y S Kanwar
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·G J NauR A Young
Nov 14, 1997·Infection and Immunity·C H LadelS H Kaufmann
Jul 6, 2000·The American Journal of Pathology·G J NauR A Young
Aug 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R Kaarteenaho-WiikP Pääkkö
Oct 6, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J SodekM D McKee
Dec 5, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·P Bornstein
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·A W O'ReganJ S Berman
Feb 8, 2003·American Journal of Respiratory and Critical Care Medicine·Yoshinobu KoguchiAtsushi Saito
Jul 8, 2003·The Journal of Pathology·Ruth Chiquet-Ehrismann, Matthias Chiquet
Sep 5, 2003·The Lancet Infectious Diseases·JoAnn M TufarielloJoAnne L Flynn
Nov 16, 2005·Nature Immunology·Chen ZhuVijay K Kuchroo
Jan 18, 2006·Clinical and Experimental Immunology·V KhajoeeT Hara
Apr 21, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Joel Fleury Djoba SiawayaGerhard Walzl
Feb 7, 2009·Clinical and Experimental Immunology·J F Djoba SiawayaG Walzl
Oct 3, 2009·Journal of Cell Communication and Signaling·Susan Amanda LundMarta Scatena
Oct 27, 2009·Nature Reviews. Microbiology·Clifton E BarryDouglas Young
Apr 14, 2010·Cancer Metastasis Reviews·Claudia ChiodoniSabina Sangaletti
Oct 13, 2010·The Journal of Experimental Medicine·Pushpa JayaramanSamuel M Behar
Jan 15, 2011·Clinical & Developmental Immunology·Suhail Ahmad
May 6, 2011·Critical Reviews in Immunology·Irina A UdalovaKim S Midwood
Jul 28, 2011·Medicinal Research Reviews·Valerie R WiersmaEdwin Bremer
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Naohisa KuriyamaAna J Coito
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Beata ShiratoriToshio Hattori
Apr 21, 2012·Nature Reviews. Immunology·Lalita Ramakrishnan
Oct 16, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Kyoko Imanaka-Yoshida
Nov 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Isabel Sada-OvalleSamuel M Behar
Jul 3, 2013·European Journal of Immunology·Friederike GiesekeIngo Müller
Oct 3, 2013·Experimental Hematology·Sarah L EllisSusan K Nilsson
Feb 14, 2015·The Journal of Infectious Diseases·Basim Al ShammariPaul T Elkington
Aug 27, 2015·Diagnostic Microbiology and Infectious Disease·Muhammad Andrian SenoputraToshio Hattori

❮ Previous
Next ❯

Citations

Mar 30, 2016·The Tohoku Journal of Experimental Medicine·Toshio HattoriElizabeth Telan
Dec 28, 2016·International Journal of Molecular Sciences·Beata ShiratoriToshio Hattori
Apr 28, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M Sevtekin, O Ozmen
Jul 19, 2019·The Journal of International Medical Research·Hangdi XuFangfang Fu
Jul 10, 2019·BioMed Research International·Biao ChenYanhua Liang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.