Evaluation of mean sphered corpuscular volume for predicting hereditary spherocytosis

International Journal of Laboratory Hematology
J BroséusFrançois Girodon

Abstract

Hereditary spherocytosis (HS) is a common red blood cell disorder. It has been shown that the mean sphered corpuscular volume (MSCV), an artificial volume, is always lower than the MCV in HS and also in some autoimmune haemolytic anaemia (AIHA). Our purpose was to assess the reliability of MSCV in routine practise, and its relevance in screening for HS. Comparison of MSCV and MCV was undertaken in a prospective study of 366 patients with anaemia. In addition, included were patients previously diagnosed to have HS (n = 33) or AIHA (n = 16). When MSCV was lower than MCV, a flow cytometric (FC) test for HS was performed. Delta (MCV-MSCV) values >9.6 fl were obtained for all HS patients. A wider spread of delta (MCV-MSCV) values was obtained for AIHA patients whose red cells gave FC test results negative for HS. In the ROC curve analysis, the determination of delta (MCV-MSCV) value has a 90.57% specificity and 100% sensitivity for HS. MSCV is a reliable automated parameter indicating possible HS. When a delta (MCV-MSCV) value is >9.6 fl, the FC test and the Coombs test are required in the differential diagnosis of HS and some AIHA.

Citations

Dec 4, 2012·Haematologica·Géraud MackiewiczFrançois Girodon
Aug 1, 2013·Archives of Pathology & Laboratory Medicine·Pianhong ZhangDongsheng Xu
Jun 11, 2014·Annals of Hematology·Elena LazarovaBéatrice Gulbis
Apr 15, 2015·European Journal of Haematology·Yuchan XuFaquan Lin
Mar 20, 2015·International Journal of Laboratory Hematology·M-J KingUNKNOWN International Council for Standardization in Haematology
Dec 9, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zengfu DengFaquan Lin
Nov 13, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Mariela Granero Farias
Apr 5, 2019·Journal of Clinical Laboratory Analysis·Lin LiaoFaquan Lin
Nov 14, 2019·Journal of Interpersonal Violence·Cynthia Fraga RizoTonya Van Deinse
Feb 13, 2018·Experimental and Therapeutic Medicine·Xiaohong LiFaquan Lin
Jun 10, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Olga CiepielaIwona Kotuła
Feb 6, 2021·Expert Review of Hematology·Elisa FermoPaola Bianchi

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