Evaluation of measles-rubella vaccination for mothers in early puerperal phase

Vaccine
Michi HisanoKoushi Yamaguchi

Abstract

The postpartum period is an ideal opportunity to vaccinate mothers with inadequate immunity to vaccine-preventable diseases including measles and rubella. A prospective study of measles-rubella (MR) vaccination in the early puerperal phase was conducted in 171 mothers, who had insufficient antibody titers when screened for immunity to measles (≤ 1:4 on the neutralization test [NT]) or rubella (≤ 1:16 on the hemagglutination inhibition [HI] test) during pregnancy. To evaluate the efficacy of MR vaccination in the postpartum period, we determined their post-vaccination antibody titers and immune responses to vaccination, and investigated the association between these and their prolactin (PRL) levels and Th1/Th2 ratios at the time of vaccination. We also examined the passage of viral RNA and antigen into breast milk. Of the 169 participants who completed the study schedule, 117 and 101 had low antibody titers against measles and rubella, respectively. In the measles-seronegative group, the antibody-positive rate was 87% on the NT assay, and the NT geometric mean antibody titer was 11.4 (95% confidence interval [CI], 10.0-13.0). In the rubella-seronegative group, the antibody-positive rate was 88% on the HI test assay, and the HI g...Continue Reading

References

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May 12, 2010·American Journal of Reproductive Immunology : AJRI·Shigeru SaitoMika Ito
Feb 3, 2011·Clinical Reviews in Allergy & Immunology·Hedi OrbachYehuda Shoenfeld
Sep 29, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B A HalperinS A Halperin

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Citations

Aug 2, 2019·Preventive Medicine Reports·Matteo BoattiniRossana Cavallo

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