PMID: 16612900Apr 15, 2006Paper

Evaluation of measured and predicted environmental concentrations of selected human pharmaceuticals and personal care products

Environmental Science and Pollution Research International
Markus LiebigThomas Knacker

Abstract

In the past few years, there was an increasing awareness of the occurrence of pharmaceuticals and personal care products (PPCPs) in surface water and drinking water resources, and measurements in surface water, sediment or waste water were done for a number of PPCPs. In the regulatory context, an environmental risk assessment (ERA) has become essential for new PPCPs. Reliably predicted or measured environmental concentrations (PECs or MECs) of chemicals are essential for the exposure assessment, which is one of the two main pillars of environmental risk assessment (ERA). This paper reports on measured data of selected PPCPs in surface waters and compares the measured values with predicted environmental concentrations from exposure models. Such models have been proposed by the European Agency for the Evaluation of Medicinal Products (EMEA) and the Technical Guidance Document on Risk Assessment for New Notified and Existing Chemical Substances (TGD). Four pharmaceuticals and one personal care product were in the scope of the investigation reported here: 17alpha-ethinylestradiol, carbamazepine, sulfamethoxazole and iopromide as well as tonalide. Measured environmental concentrations in surface waters for these PPCPs were reviewed ...Continue Reading

Citations

Feb 4, 2010·Journal of Environmental Engineering·William D Wombacher, Keri C Hornbuckle
Mar 15, 2014·Environmental Science and Pollution Research International·Pravin K Mutiyar, Atul K Mittal
Feb 22, 2018·Environmental Science. Processes & Impacts·Yu-Mei TanPeter Egeghy
Jul 28, 2009·Analytical and Bioanalytical Chemistry·Arnold BahlmannRudolf J Schneider
Jun 29, 2014·Environmental Science and Pollution Research International·Thomas L ter LaakJan Hofman
Jan 29, 2017·Environmental Science and Pollution Research International·Wen-Da OhTeik-Thye Lim
May 10, 2017·Environmental Toxicology and Chemistry·Emily E BurnsAlistair B A Boxall
Oct 2, 2007·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Thomas Lundeberg, Iréne Lund
Aug 29, 2007·Environmental Science and Pollution Research International·Kees van Leeuwen
Aug 9, 2008·Environmental Science and Pollution Research International·Ki-Dong KwonWoo-Sik Jeong
Jun 15, 2020·International Journal of Hygiene and Environmental Health·Tanguy PouzolJean-Luc Bertrand-Krajewski
Jan 5, 2013·The Science of the Total Environment·Sheyla Ortiz de GarcíaRubén Irusta Mata
Sep 23, 2014·Environmental Science & Technology·Hanna Maja MaesAndreas Schaeffer
Oct 16, 2007·The Science of the Total Environment·Mitchell S Kostich, James M Lazorchak
Dec 6, 2021·The Science of the Total Environment·Karen DuisAnja Coors

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