Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants.

Malaria Journal
Marc TwagirumukizaM Luc Van Bortel

Abstract

To compare three methods for evaluating treatment adherence in a 7-day controlled treatment period for malaria in children in Rwanda. Fifty-six children (< 5 years) with malaria were recruited at the University Hospital of Butare, Rwanda. Patients were treated with quinine sulfate, taste-masked, pellets during seven days: three days in hospital (in-patient) followed by a four-day out-patient period. Three methods to evaluate medication adherence among patients were compared: manual pill count of returned tablets, patient self-report and electronic pill-box monitoring. These pill-boxes were equipped with a microchip registering date and time of every opening. Medication adherence was defined as the proportion of prescribed doses taken. The inter-dose intervals were analysed as well. Medication adherence data were available for 54 of the 56 patients. Manual pill count and patient self-report yielded a medication adherence of 100% for the in- and out-patient treatment periods. Based on electronic pill-box monitoring, medication adherence during the seven-day treatment period was 90.5 +/- 8.3%. Based on electronic pill-box monitoring inpatient medication adherence (99.3 +/- 2.7%) was markedly higher (p < 0.03) than out-patient adhe...Continue Reading

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Citations

Nov 2, 2011·AIDS and Behavior·David J MooreUNKNOWN HIV Neurobahavioral Research Program (HNRP)
Jun 13, 2012·AIDS Patient Care and STDs·Jayraan BadieeUNKNOWN Hiv Neurobehavioral Research Program (HNRP) Group
Oct 30, 2013·The American Journal of Tropical Medicine and Hygiene·Anjana FuangchanChuenjid Kongkaew
Apr 25, 2021·Clinical Pharmacology and Therapeutics·Larissa WenningJennifer E Hibma

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