PMID: 11329713May 2, 2001Paper

Evaluation of methods for predicting the toxicity of polycyclic aromatic hydrocarbon mixtures

Environmental Science & Technology
W R ReevesK C Donnelly

Abstract

Risk assessments of polycyclic aromatic hydrocarbon mixtures are hindered by a lack of reliable information on the potency of both mixtures and their individual components. This paper examines methods for approximating the toxicity of polycyclic aromatic hydrocarbon (PAH) mixtures. PAHs were isolated from a coal tar and then separated by ring number using HPLC. Five fractions (A-E) were generated, each possessing a unique composition and expected potency. The toxicity of each fraction was measured in the Salmonella/mutagenicity assay and the Chick Embryo Screening Test (CHEST). Their abilities to induce ethoxyresorufin-O-deethylase and to inhibit gap junction intercellular communication in rat liver Clone 9 cells were also measured. In the Salmonella/mutagenicity assay, fractions were predicted to have potencies in the order C > D > E > B > A. Toxic equivalency factors (TEFs) for fractions A-E were in the order E > or = D > C > B > A. TEF values were 20,652, 20,929, 441, 306, and 74.1 micrograms of BaP equiv/g, respectively. A lack of agreement between assay-predicted potencies and chemical analysis-predicted potencies was observed with other assays and other methods of calculation. The results demonstrate the limitations of us...Continue Reading

References

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Citations

Jul 10, 2003·Journal of Toxicology and Environmental Health. Part a·Leslie CizmasKirby C Donnelly
May 13, 2011·Environmental Health Perspectives·Julia M GohlkeTimothy Fitzgerald
Jul 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·Mathieu VinkenVera Rogiers
Dec 12, 2012·Toxicology and Applied Pharmacology·Ian W H JarvisKristian Dreij
Nov 26, 2004·Risk Analysis : an Official Publication of the Society for Risk Analysis·Leslie M ShorGary L Taghon
Jan 17, 2012·Environmental Pollution·Elba Calesso TeixeiraFlavio Wiegand
May 23, 2014·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Andrea Szabó NagyIstván Vass
Oct 19, 2016·Environmental Science & Technology·Stephen M RobertsYvette Lowney
Nov 15, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Huey-Min HwangXueheng Zhao
Oct 30, 2004·International Journal of Toxicology·Aramandla RameshEric H Weyand
Jan 25, 2006·Psychopharmacology·Mehmet SofuogluThomas Kosten
Dec 6, 2017·Environmental Science and Pollution Research International·Chase S BrewsterThomas J McDonald
Sep 12, 2015·Risk Analysis : an Official Publication of the Society for Risk Analysis·Stacey J Gaskill, Erica D Bruce
Nov 24, 2019·The Science of the Total Environment·Anne-Antonella SerraGwenola Gouesbet

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