Evaluation of microRNA-205 expression as a potential triage marker for patients with low-grade squamous intraepithelial lesions

Oncology Letters
Hong XieS Andersson

Abstract

High-risk human papillomavirus (HPV) testing is a recommended triage approach for females with atypical squamous cells of undetermined significance (ASCUS), but due to its poor specificity this approach is not recommended for patients with low-grade squamous intraepithelial lesions (LSIL). The objective of the current study was to determine microRNA (miR)-205 expression levels in liquid-based cytology (LBC) samples, and evaluate their ability to predict cervical intraepithelial neoplasia grade 2/3 or worse (CIN2/3+) in females with minor cytological abnormalities. LBC samples were obtained from patients attending the Swedish Cervical Cancer Screening Program. The Mann-Whitney U test, one-way analysis of variance, Kruskal-Wallis test, Spearman rank order correlation analysis, and Pearson's χ(2) test were used to assess the results. Accuracy analyses indicated that high miR-205 expression had a significantly higher specificity to high-risk HPV testing, and a sensitivity similar to that of high-risk HPV testing to predict CIN2+ and CIN3+ in women with LSIL, but not those with high-grade squamous intraepithelial lesions. Although further research is required for females with LSIL, miR-205 expression in LBC samples may be a novel tr...Continue Reading

References

Sep 16, 1999·British Journal of Cancer·R BergströmH O Adami
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Diane SolomonUNKNOWN Bethesda 2001 Workshop
Jun 12, 2002·Current Treatment Options in Oncology·K H Lu, T W Burke
Nov 26, 2002·Virus Research·F Xavier Bosch, Nubia Muñoz
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Apr 6, 2006·International Journal of Cancer. Journal International Du Cancer·Jack CuzickThomas Iftner
Dec 23, 2006·Nature Reviews. Cancer·Ciaran B J WoodmanLawrence S Young
Jul 10, 2007·Cancer Research·Weng-Onn LuiAndrew Fire
Oct 19, 2007·The New England Journal of Medicine·Pontus NauclerJoakim Dillner
Sep 27, 2008·Annual Review of Pathology·Yong Sun Lee, Anindya Dutta
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Apr 27, 2011·International Journal of Cancer. Journal International Du Cancer·Paolo Giorgi-RossiGuglielmo Ronco
Dec 7, 2011·Methods in Molecular Biology·Boye Schnack Nielsen
Jan 3, 2013·European Journal of Cell Biology·Ai-Ying QinShui Cao
Feb 6, 2013·PloS One·Meiye WuAnup K Singh
Jul 4, 2013·Genetic Testing and Molecular Biomarkers·Shan ZhaoNan Ding
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xiaohong WangZhi-Ming Zheng
Apr 11, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Norodiyah Othman, Nor Hayati Othman
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ayla Valinezhad OrangMohammad Hossein Somi
Sep 6, 2014·Journal of the National Cancer Institute·Qifang TianXing Xie
Sep 15, 2014·Methods in Molecular Biology·Meiye WuAnup K Singh
Jan 1, 2014·Cancer Cell International·Quanhui MaXiaoming Yao
Jun 13, 2015·Molecular Diagnosis & Therapy·Mariana MaltaHugo Sousa
Jul 1, 2015·Genes & Cancer·Hoda A HagrassRasha Kassem
Jul 3, 2015·International Journal of Oncology·Ryoji NonakaMasaki Mori
Jul 17, 2015·Anti-cancer Agents in Medicinal Chemistry·Jing YuXinguo Zhu
Aug 4, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hiroki ImaokaMasato Kusunoki
Sep 1, 2015·Clinical Chemistry·Yuqing HeKai Wang

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Citations

May 7, 2021·BioMed Research International·Rhafaela L CausinMárcia M C Marques
Aug 14, 2021·Obstetrics & Gynecology Science·Kavitha NagandlaMohamed Faiz Bin Mohamed Jamli

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