Evaluation of microvessel density (MVD) in canine mammary tumours by quantitative immunohistochemistry of the claudin-5 molecule

Acta Veterinaria Hungarica
Csaba JakabJanina Kulka

Abstract

In our recent investigation, angiogenesis was evaluated and quantified by immunohistochemical evaluation of microvessel density (MVD) using claudin-5 (CLDN-5) as a marker for vascular endothelium in 67 canine mammary gland tumours. Computer image analysis was used to measure the intratumoural MVD. Higher intratumoural MVD was detected in malignant simple neoplasms compared with benign tumours. Furthermore, the results of MVD were correlated with histological grade, higher grades being accompanied by higher MVD. In simple adenomas and grade I tubular-tubulopapillary simple carcinomas the intratumoural microvessels were wide and regular in shape with evident erythrocytes in their lumen. In grade III solid carcinomas the microvessels were smaller, less regular and had irregular shape, often without a distinct lumen, and isolated endothelial cells were frequently present. In the complex carcinomas MVD was low and the intratumoural microvessels were mostly irregular in shape without a distinct lumen. The evaluation of MVD by CLDN-5 immunohistochemistry may give useful additional information on the angiogenic potential of breast cancers in dogs.

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Citations

Aug 3, 2010·The Veterinary Journal·Felisbina L QueirogaCarlos S Lopes
Feb 9, 2010·Veterinary Dermatology·Csaba JakabJanina Kulka
Aug 18, 2010·Acta Veterinaria Hungarica·Csaba JakabJanina Kulka
Jul 9, 2009·Acta Veterinaria Hungarica·Csaba JakabPéter Gálfi
Jul 6, 2011·Acta Veterinaria Hungarica·Péter CsébiLászló Kóbori
May 22, 2009·Acta Veterinaria Hungarica·Csaba JakabTibor Németh
Nov 16, 2013·Journal of Comparative Pathology·N SleeckxC Van Ginneken
Dec 15, 2010·Veterinary Pathology·R KlopfleischA D Gruber
Nov 10, 2009·Acta Veterinaria Hungarica·Csaba JakabJanina Kulka
Jul 29, 2009·Acta Veterinaria Hungarica·Katalin KovácsAttila Marcell Szász

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