Evaluation of mixed effects in event-related fMRI studies: impact of first-level design and filtering

NeuroImage
M BianciardiG E Hagberg

Abstract

With the introduction of event-related designs in fMRI, it has become crucial to optimize design efficiency and temporal filtering to detect activations at the 1st level with high sensitivity. We investigate the relevance of these issues for fMRI population studies, that is, 2nd-level analysis, for a set of event-related fMRI (er-fMRI) designs with different 1st-level efficiencies, adopting three distinct 1st-level filtering strategies as implemented in SPM99, SPM2, and FSL3.0. By theory, experiments, and simulations using physiological fMRI noise, we show that both design and filtering impact the outcome of the statistical analysis, not only at the 1st but also at the 2nd level. There are several reasons behind this finding. First, sensitivity is affected by both design and filtering, since the scan-to-scan variance, that is the fixed effect, is not negligible with respect to the between-subject variance, that is the random effect, in er-fMRI population studies. The impact of the fixed effects error on the sensitivity of the mixed effects analysis can be mitigated by an optimal choice of er-fMRI design and filtering. Moreover, the accuracy of the 1st- and 2nd-level parameter estimates also depend on design and filtering; espec...Continue Reading

References

Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E BullmoreP Sham
Mar 1, 1995·NeuroImage·K J FristonR Turner
Sep 1, 1995·NeuroImage·K J Worsley, K J Friston
Sep 24, 1999·NeuroImage·K J FristonK J Worsley
Oct 19, 1999·Human Brain Mapping·A M Dale
Nov 5, 1999·NeuroImage·K J FristonA M Dale
Jun 22, 2000·NeuroImage·D J McGonigleA P Holmes
Nov 15, 2001·NeuroImage·M W WoolrichS M Smith
Jan 5, 2002·NeuroImage·K J WorsleyA C Evans
May 29, 2002·NeuroImage·K J FristonJ Ashburner
May 29, 2002·NeuroImage·K J FristonJ Ashburner
Apr 2, 2003·NeuroImage·Andrea MechelliKarl J Friston
Oct 22, 2003·NeuroImage·Christian F BeckmannStephen M Smith

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Citations

May 12, 2011·Journal of Cognitive Neuroscience·Zheng YeThomas F Münte
Oct 31, 2013·Journal of Neurotrauma·Patrice PéranRita Formisano
Mar 17, 2010·Brain Research·Patrice PéranUmberto Sabatini
Apr 17, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Patrice PéranUmberto Sabatini
Aug 23, 2008·Biological Psychiatry·Cameron S CarterStephen Strother
Oct 2, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G C FeiglM Samii
Jun 30, 2007·NeuroImage·Marta BianciardiAlfredo Colosimo
May 14, 2011·Human Brain Mapping·Bärbel MausMartijn P F Berger
Mar 30, 2006·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Stephen C Strother
May 18, 2010·NeuroImage·Hsiao-Ying WeyTimothy Q Duong
Mar 17, 2011·NeuroImage·Bärbel MausMartijn P F Berger
Nov 14, 2006·NeuroImage·Andrew T SmithJoshua H Balsters
Sep 11, 2012·Journal of Neuroscience Methods·M Welvaert, Y Rosseel
Mar 23, 2019·Nature Communications·Wiktor OlszowyGuy B Williams

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