Evaluation of molecular markers in low-grade diffuse astrocytomas: loss of p16 and retinoblastoma protein expression is associated with short survival

The American Journal of Surgical Pathology
David A HiltonSeth Love

Abstract

Diffuse astrocytomas have a median survival of 6-8 years. However, in a minority of cases that are histologically low grade, progression is rapid, leading to death within 2 years. Loss of p16, retinoblastoma protein, and deleted-in-colon-carcinoma protein expression, and monosomy of chromosome 10 have been shown to occur in malignant astrocytic tumors. We have investigated the prognostic value of expression of these markers, using techniques applicable in many histopathology laboratories, in diffuse astrocytomas that are histologically low grade. Paraffin sections from 71 diffuse, supratentorial, low-grade astrocytomas, from patients with at least 8-year survival data, were immunostained with antibodies to p16, deleted-in-colon-carcinoma protein, p53, Ki67, and retinoblastoma protein. In situ hybridization with a digoxigenin-labeled probe to chromosome 10 was used to assess chromosomal loss. In most cases there was immunostaining of virtually all tumor cell nuclei with antibodies to p16 and retinoblastoma protein. Three of the 68 tumors in which assessment of p16 was possible included discrete foci with lack of detectable immunoreactivity in tumor cells. The three patients concerned had a significantly shortened median survival...Continue Reading

References

Dec 1, 1987·Cancer Genetics and Cytogenetics·J A ReyS Moreno
Oct 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·D W EllisonR O Weller
Aug 1, 1995·Journal of Neurosurgery·S J DalrympleR B Jenkins
Jul 1, 1993·Genes, Chromosomes & Cancer·D Fults, C Pedone
Nov 1, 1994·Annals of Neurology·J W HensonD N Louis
Jul 6, 1994·Journal of the National Cancer Institute·D J van MeyelJ G Cairncross
Mar 1, 1994·British Journal of Cancer·P IuzzolinoM Barbareschi
Jan 1, 1993·Brain Pathology·A von DeimlingD N Louis
Oct 1, 1996·Journal of Neuropathology and Experimental Neurology·Y OnoD N Louis
Jul 1, 1996·Journal of Neuropathology and Experimental Neurology·J ReifenbergerG Reifenberger
Aug 1, 1997·Journal of Neuro-oncology·D SchifferM T Giordana
Oct 24, 1998·Journal of Neuropathology and Experimental Neurology·P E McKeeverM Blaivas
Mar 5, 1999·Journal of Neuro-oncology·K NakataniN Sakai

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Citations

Aug 19, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Guido Reifenberger, Vincent Peter Collins
Jan 17, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Muhittin BelirgenM Memet Ozek
Sep 16, 2008·Clinical and Experimental Medicine·Tao SongJiesheng Fang
May 2, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Tetsuya Shiraishi, Kazuo Tabuchi
Jan 10, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Vassiliki ZolotaChrisoula D Scopa
Nov 26, 2008·Journal of Neurosurgery·Wei-Ying YueZhong-Ping Chen
Sep 28, 2010·World Journal of Gastroenterology : WJG·Yun ZhangYan-Yan Song
Dec 1, 2007·Expert Opinion on Medical Diagnostics·Fatima W Khwaja
Jan 18, 2007·Neurosurgery·Marcus L WareBurt G Feuerstein
Nov 7, 2003·Genes, Chromosomes & Cancer·Peter H WesselsAnton H N Hopman

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