Abstract
Studies have shown that N-methyl-D-aspartate (NMDA) receptors play a critical role in morphine analgesia and motoric processes at different levels of the central nervous system. In this study, we used cortex-specific NR1 knockout (KO) mice (C57BL/6 strain) to elucidate the role of cortical NMDA receptors in morphine analgesia and motor coordination. On post-natal day 20, mice (CTL and KO) received vehicle (saline) or morphine (10 mg/kg) and paw withdrawal latency (PWL) to a noxious thermal stimulus was measured. On post-natal day 21, motor coordination was measured using the rotating pole test. No differences in KO mice were found with respect to PWL following administration of saline or morphine (p>0.05). However, sex-dependent differences were found in motor coordination, with male KO mice showing a greater motor impairment in the rotating pole test than female KO mice (p<0.05). The present results demonstrate that NMDA receptors are involved in both the analgesic effects of morphine and motor coordination, with the existence of sex-related differences in motor coordination.
References
Sep 23, 1988·European Journal of Pharmacology·Y F Jacquet
Jan 1, 1988·Pain·K HargreavesJ Joris
Aug 1, 1994·Neuron·D ForrestT Curran
Feb 1, 1996·Neuron·T KutsuwadaM Mishina
Feb 11, 1998·Cell·R SprengelP H Seeburg
Aug 26, 1998·Pain·C J Teng, F V Abbott
Oct 10, 1998·Pain·M KavaliersE Choleris
Jun 18, 1999·The Journal of Clinical Endocrinology and Metabolism·B S McEwen
Apr 25, 2000·Journal of Neuroscience Methods·G J MattiassonT K McIntosh
Jul 5, 2001·European Journal of Pharmacology·E KozelaP Popik
Oct 10, 2002·Amino Acids·E Kozela, P Popik
Mar 7, 2003·Human Movement Science·Jan P PiekIan Case
Sep 23, 2003·Anesthesia and Analgesia·Andrei B PetrenkoKoki Shimoji
May 26, 2004·Pain·Kumar V S NemmaniJeffrey S Mogil
Jun 11, 2005·Life Sciences·Minoru NaritaTsutomu Suzuki
Sep 5, 2006·Frontiers in Neuroendocrinology·Markus KippCordian Beyer
Sep 8, 2007·Neuroscience Letters·Gabriel C QuinteroAnthony L Vaccarino
Sep 21, 2007·The European Journal of Neuroscience·Stephan NiemannYasunori Hayashi
Citations
Apr 5, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kathy Ruth MagnussonPeter R Patrylo
Jun 30, 2011·The Clinical Journal of Pain·Jo NijsRob A B Oostendorp
Oct 2, 2009·Peptides·Richard J Bodnar
Sep 20, 2011·Pharmacology, Biochemistry, and Behavior·Mohadeseh Ghalandari-ShamamiAbbas Haghparast
Aug 7, 2010·Pain·Luis Felipe S Da SilvaKathleen A Sluka
Jun 1, 2017·NPJ Schizophrenia·Kazu NakazawaKazuhito Nakao
May 27, 2021·Journal of Neurophysiology·Shekib A JamiJohn A Gray