Evaluation of mortality, disease activity, treatment, clinical and immunological features of adult and late onset systemic Lupus erythematosus

Autoimmunity
Stefania CartellaF Franceschini

Abstract

We retrospectively compared disease activity, treatment, clinical and laboratory features, and rate of mortality of 535 SLE patients with adult and late disease onset. patients were divided into two groups based on the onset of the disease before or after 50 years of age. Clinical data were collected from medical reports. Disease activity was measured by ECLAM score. Parameters were compared by χ²-test, Fisher's test, Student's t or the Mann-Whitney test. Forty patients (7.5%) were included in the late SLE onset group (group A), while 495 (92.5%) in the adult SLE onset group (group B). Sicca symptoms were more frequent in group A (p < 0.0008), while glomerulonephritis (p < 0.0069), reduced C3 (p < 0.0006) and low C3 (p < 0.00002) and C4 levels (p < 0.0006) were more prevalent in group B. Twenty-two deaths (4.3%) were recorded: 14 (2.8%) in group B and 8 (20%) in group A. Deaths were mainly due to infections in group B (28.5%) and cardiovascular events in group A (50%). A lower use of HCQ and LDA were recorded in deceased versus living patients (p < 0.0001 and 0.0166, respectively), while a higher ECLAM score was measured at onset in dead versus living patients (p < 0.048). Late onset SLE occurred in 7.5% of patients and it was ...Continue Reading

References

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Citations

May 14, 2014·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Sep 4, 2014·Autoimmunity Reviews·Eyal ZimlichmanGisele Zandman-Goddard
Mar 15, 2016·Seminars in Arthritis and Rheumatism·Jennifer L MedlinChristie M Bartels
Mar 18, 2016·Current Rheumatology Reports·César E Fors Nieves, Peter M Izmirly
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Nov 20, 2016·Clinical Rheumatology·Rafael Hennemann SassiOdirlei André Monticielo

Related Concepts

Cause of Death
Lupus Erythematosus, Systemic
Retrospective Studies
Late Onset Disorders
Cardiovascular Diseases
Complement component C4
Cessation of Life
Dopamine
Glomerulonephritis
Hydroxychloroquine

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