Evaluation of multi-neuroprotective effects of erythropoietin using cisplatin induced peripheral neurotoxicity model

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Nivin SharawyMagdy Fouad Youakim

Abstract

Cisplatin (CDDP) is severely neurotoxic anti-neoplastic drug that causes peripheral neuropathies with clinical signs known as chemotherapy-induced peripheral neurotoxicity. The ameliorating effects of erythropoeitin on cisplatin-induced neuropathy, which seem to be mediated by enhancing the cell resistance to side effects of cisplatin rather than by influencing the formation or repair rates of cisplatin-induced cross-links in the nuclear DNA, had been previously reported. The main objective of our study is to investigate the roles of nitro-oxidative stress, nuclear factor kappa B (NFκB) gene expressions and TNF levels on the previous reported erythropoietin anti-apoptotic neuroprotective effects during cisplatin induced neurotoxicity. The present study compared the effects of erythropoietin (50 μg/kg/d thrice weekly) on cisplatin (2mg/kg/d i.p. twice weekly for 4 weeks) induced neurophysiologic changes and the associated changes in the inflammatory mediators (TNF alpha and NFKB), oxidative stress (malondialdehyde (MDA), superoxide dismutases (SOD) and glutathione) and gene expression of both neuronal nitric oxide synthase (nNOS) and inducible nitric oxide synthase (iNOS). In addition, sciatic nerve pro-apoptotic and anti-apopto...Continue Reading

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Citations

Apr 7, 2016·Acta Cirúrgica Brasileira·Kürşat KayaNeşe Başak
Jan 22, 2020·Journal of Food Biochemistry·Nurhan AkarasMurat Gul
Mar 27, 2019·International Journal of Molecular Sciences·Renata ZajączkowskaJerzy Wordliczek
Mar 17, 2020·Frontiers in Pharmacology·Melis Debreli CoskunShaker A Mousa
Jan 1, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Neife Aparecida Guinaim Dos SantosAntonio Cardozo Dos Santos
Mar 3, 2021·The International Journal of Neuroscience·Filiz KazakMehmet Zeki Yılmaz Deveci
Jun 29, 2021·Neuroscience Letters·Timothy M Doyle, Daniela Salvemini
Jun 29, 2021·Cutaneous and Ocular Toxicology·Ufuk OkkayAhmet Hacimuftuoglu
Aug 15, 2021·Basic & Clinical Pharmacology & Toxicology·Sara A WahdanEbtehal El-Demerdash
Oct 17, 2021·Oncology and Therapy·Jamie BurgessUazman Alam

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