PMID: 7546911Jul 1, 1995Paper

Evaluation of murine leukemia virus infection as a model for thrombocytopenia of HIV/AIDS: mechanism of thrombocytopenia and modulation of thrombocytopenia by thrombopoietin

AIDS Research and Human Retroviruses
P S Sullivan, T P McDonald

Abstract

Infection of mice with the murine leukemia virus (LP-BM5) was evaluated as a model for the thrombocytopenia of HIV/AIDS. Percent 35S incorporation into platelets, platelet size, platelet count, platelet-associated immunoglobulins (PAIgG), and megakaryocyte size and number were evaluated over a period of 3-9 weeks postinfection (PI). Thrombopoietin from human embryonic kidney cells was administered to mice 9 weeks PI, and similar indices of platelet production were measured 2, 3, and 4 days after treatment with a biological preparation of thrombopoietin (thrombocytopoiesis-stimulating factor, or TSF). Platelet counts decreased in a time-dependent fashion (p = 0.0006) following infection, reaching a nadir at 8 weeks PI (82% of control values). Percent 35S incorporation into platelets also decreased over the 9-week period (p = 0.0001), falling to 63% of control values by week 9. Additionally, platelet volume increased in a linear fashion (p = 0.01), rising to 105% of control values by week 9. No changes in PAIgG were noted over the 9-week period. Megakaryocyte numbers in the femoral marrow were decreased at 8 weeks PI (p = 0.02, 78% of control values), while increased mean megakaryocyte size (p = 0.007, 116% of controls) was noted...Continue Reading

References

Mar 1, 1992·European Journal of Haematology·E M SloandP Pierce
Feb 1, 1991·Journal of Virology·S C CheungP M Pitha
Jul 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P Jolicoeur
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S K ChattopadhyayJ W Hartley
Dec 1, 1987·American Journal of Hematology·Z Bel-AliY Najean
Dec 1, 1970·Virology·W P RoweJ W Hartley
Dec 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·T P McDonald

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Citations

Jan 18, 2007·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Cecily D Cosby
Mar 4, 2000·Pediatric Clinics of North America·M Laufer, G B Scott

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