PMID: 9661996Jul 14, 1998Paper

Evaluation of muscarinic M2 receptor sites in basal forebrain and brainstem cholinergic systems of behaviorally characterized young and aged Long-Evans rats

Neurobiology of Aging
T M Gill, M Gallagher

Abstract

Aged (23-25-month-old) male Long-Evans rats were assessed for deficits in spatial cognition relative to young (4-6-month-old) rats. An in vitro autoradiography study was then conducted for muscarinic M2 sites using [3H]AF-DX 384 to assess binding in basal forebrain and brainstem areas where cholinergic neurons are localized. The analysis of basal forebrain included the medial septal/diagonal band region that provides cholinergic innervation of the hippocampus; the laterodorsal tegmental nucleus and pedunculopontine tegmental nucleus were analyzed in the brainstem. A significant age-related reduction in M2 binding was found in both the basal forebrain and brainstem. Only the reduction in the basal forebrain, however, was correlated with spatial learning impairment. Although the basal forebrain and brainstem cholinergic systems are each vulnerable in normal aging, contributions to the behavioral effects of aging may be distinctive for the two systems.

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Citations

Mar 24, 2004·Experimental Gerontology·Seyed Khosrow TayebatiFrancesco Amenta
Feb 20, 2003·Neurobiology of Learning and Memory·Leticia Ramírez-LugoFederico Bermúdez-Rattoni
Sep 28, 2007·Investigative Ophthalmology & Visual Science·Hiroshi ToshidaAkira Murakami
Sep 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·R Jonathan RobitsekHoward Eichenbaum
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Brandon ChristianMona McConnaughey
Dec 8, 2004·The European Journal of Neuroscience·Zachariah JonassonMark G Baxter
Mar 8, 2005·Neurobiology of Aging·Iain A WilsonHeikki Tanila

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