PMID: 9683391Jul 31, 1998Paper

Evaluation of muscle protein mass in children with solid tumors by muscle thickness measurement with ultrasonography, as compared with anthropometric methods and visceral protein concentrations

European Journal of Clinical Nutrition
M Taskinen, U M Saarinen-Pihkala

Abstract

To compare the merits of regional ultrasonography, anthropometry, and measurement of visceral protein concentrations for determining muscle protein mass and nutritional status. Prospective follow-up study. Nineteen children (median age 4.7 y, range, 1.4-14.1 y) with malignant solid tumors were examined at diagnosis, monthly during preoperative chemotherapy, and 1-2 months after operation; 19 healthy age- and sex-matched children served as controls. We measured the thickness of the quadriceps muscle by ultrasonography (muscle index), and body weight, mid-arm circumference, triceps skinfold thickness, and serum concentrations of albumin, prealbumin, and transferrin. At diagnosis, the muscle index was smaller in the patients (mean 5.6 cm2/m2, 95% CI 4.5-6.7 cm2/m2) than in the controls (8.5 cm2/m2, 95% CI 7.7-9.3 cm2/m2) (P = 0.0007), whereas the anthropometric measurements did not differ. The sensitivity, specificity, and predictive value of anthropometry and measurements of visceral proteins were poor in detecting reduced muscle protein reserves when compared with the muscle index as the baseline standard. During the anticancer therapy the mean concentrations of serum albumin and prealbumin increased. In children with cancer, nu...Continue Reading

Citations

Feb 22, 2012·Bone Marrow Transplantation·L J BechardC Duggan
Jan 24, 2012·Critical Reviews in Oncology/hematology·Aeltsje BrinksmaWim Tissing
Sep 6, 2012·Pediatric Blood & Cancer·Erica Co-ReyesJoya Chandra
Nov 2, 2014·Pediatric Blood & Cancer·Aeltsje BrinksmaWim J E Tissing
Jan 31, 2006·São Paulo Medical Journal = Revista Paulista De Medicina·Adriana GarófoloAntonio Sérgio Petrilli
Jun 21, 2003·The American Journal of Clinical Nutrition·Christopher DugganEva Guinan

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