Evaluation of mutagenic and antimutagenic activities of alpha-bisabolol in the Salmonella/microsome assay

Mutation Research
M R Gomes-CarneiroF J R Paumgartten

Abstract

alpha-Bisabolol (BISA) is a sesquiterpene alcohol found in the oils of chamomile (Matricaria chamomilla) and other plants. BISA has been widely used in dermatological and cosmetic formulations. This study was undertaken to investigate the mutagenicity and antimutagenicity of BISA in the Salmonella/microsome assay. Mutagenicity of BISA was evaluated with TA100, TA98, TA97a and TA1535 Salmonella typhimurium strains, without and with addition of S9 mixture. No increase in the number of his+ revertant colonies over the negative (solvent) control values was observed with any of the four tester strains. In the antimutagenicity assays, BISA was tested up to the highest nontoxic dose (i.e. 50 and 150 microg/plate, with and without S9 mix, respectively) against direct-acting (sodium azide, SA; 4-nitroquinoline-N-oxide, 4-NQNO; 2-nitrofluorene, 2-NF; and nitro-o-phenylenediamine, NPD) as well as indirect-acting (cyclophosphamide, CP; benzo[a]pyrene, B[a]P; aflatoxin B1, AFB1; 2-aminoanthracene, 2-AA; and 2-aminofluorene, 2-AF) mutagens. BISA did not alter mutagenic activity of SA and of NPD, and showed only a weak inhibitory effect on the mutagenicity induced by 4-NQNO and 2-NF. The mutagenic effects of AFB1, CP, B[a]P, 2-AA and 2-AF, on...Continue Reading

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Citations

Jul 31, 2013·Steroids·Ana Paula Siqueira de OliveiraEliana Aparecida Varanda
Dec 25, 2010·Journal of Medicinal Food·Jaouad AnterAndrés Muñoz-Serrano
May 23, 2012·Organic and Medicinal Chemistry Letters·Gerlânia de Oliveira LeiteAdriana Rolim Campos
Jul 8, 2011·Genetics and Molecular Biology·Natália Cassettari de CarvalhoVanessa Moraes de Andrade
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