PMID: 9541658Apr 29, 1998Paper

Evaluation of mutant frequencies at the hprt and the T-cell receptor loci in pediatric cancer patients before treatment

Mutation Research
M SawadaK Furusho

Abstract

Mutant frequencies (Mfs) at the two genetic loci, the hypoxanthine phosphoribosyl transferase (hprt) gene and the T-cell receptor (TCR) gene were evaluated in pediatric cancer patients before starting chemotherapy or radiotherapy. The study population consisted of 27 patients with various solid tumors (mean age +/- SD; 5.5 +/- 5.1 years, range; 0.2-14.5 years), 5 patients with acute leukemia (10.3 +/- 6.1, 1.3-17.0 years), and 26 healthy controls (11.6 +/- 4.0, 4.4-22.2 years). Although the age distributions were different, the mean Mf values of the hprt and the TCR loci were comparable among these three groups. On an individual basis taking the age factor into consideration, the hprt-Mfs of 3 patients with solid tumors, i.e., two patients with Hodgkin's disease and one patient with Askin tumor, were found to be well above the 95% confidence limit. There were no patients with a TCR-Mf exceeding the 95% confidence limit. These data suggest the possibility that some patients with solid tumors may be predisposed to mutational susceptibility before treatment. The assay of the hprt-Mf appears more sensitive than the TCR-Mf assay in distinguishing these patients.

References

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Citations

May 30, 2002·Mutation Research·Keigo HamahataTatsutoshi Nakahata
Oct 12, 2000·Mutation Research·M KubotaY Wakazono
Oct 30, 2007·The Journal of Toxicological Sciences·Naoki KunugitaToshiyuki Norimura
Jul 23, 2003·Environmental and Molecular Mutagenesis·Sederick C RiceBarry A Finette
May 8, 2018·Medical Oncology·Michelle H TownsendKim L O'Neill
Jul 3, 2004·Cancer Research·Sederick C RiceBarry A Finette

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