PMID: 8582137Aug 1, 1995Paper

Evaluation of mycobacteria growth indicator tubes for susceptibility testing of Mycobacterium tuberculosis to isoniazid and rifampin

Diagnostic Microbiology and Infectious Disease
B S ReisnerG L Woods

Abstract

The reliability of mycobacteria growth indicator tubes (MGIT) for determining the susceptibility of Mycobacterium tuberculosis to isoniazid (0.1 microgram/ml) and rifampin (2.0 micrograms/ml) was evaluated by comparing MGIT results to those obtained by the radiometric BACTEC TB method. We tested 29 isolates, many selected for resistance. The turnaround times were 3-8 days (median 6) for MGIT and 4-10 days (median 6) for BACTEC. Isoniazid results by both methods agreed for all isolates tested: 20 resistant and nine susceptible. Rifampin results agreed for 28 isolates: 10 resistant and 18 susceptible. One isolate yielded discrepant results: resistant to rifampin by BACTEC, but susceptible by MGIT. This isolate was also rifampin-resistant by the traditional Method of Proportion and when tested by the MGIT method using 1.0 micrograms/ml of rifampin. The MGIT system is a nonradiometric alternative to the BACTEC for rapid susceptibility testing of M. tuberculosis to isoniazid and rifampin; however, additional testing is needed to determine the optimal concentration of rifampin.

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Citations

Jul 1, 1997·Diagnostic Microbiology and Infectious Disease·J S Bergmann, G L Woods
Mar 5, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Christoph Lange, Toru Mori
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Takemasa TakiiKikuo Onozaki
Apr 30, 2013·Emerging Infectious Diseases·Max R O'DonnellC Robert Horsburgh
Jul 17, 2008·Journal of Microbiological Methods·Juan Carlos PalominoFrancoise Portaels
Jan 20, 2004·Tropical Medicine & International Health : TM & IH·Richard J Coker
Sep 1, 2012·International Journal of Mycobacteriology·Senia Rosales-KlintzSven E Hoffner
Dec 1, 2013·International Journal of Mycobacteriology·Mehedi HasanRashed Noor
Feb 22, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Pablo ZapataJavier Aznar
Feb 13, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E A MacondoS Mboup
Nov 9, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M A S TellesD N Sato
May 24, 2012·Expert Review of Molecular Diagnostics·Scott K Heysell, Eric R Houpt
Oct 5, 2007·Expert Review of Anti-infective Therapy·Alberto MatteelliMario Raviglion
Jun 19, 2019·Nature Reviews. Microbiology·Conor J MeehanAnnelies Van Rie

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