Evaluation of myocardial deformation in patients with sickle cell disease and preserved ejection fraction using three-dimensional speckle tracking echocardiography.

Echocardiography
Homaa AhmadVictor Mor-Avi

Abstract

Sickle cell disease (SCD) is a hemoglobinopathy that affects one in 500 African Americans. Although it is well established that patients with SCD have left ventricular (LV) diastolic dysfunction, it is not clear whether they have subtle LV systolic dysfunction despite preserved ejection fraction (EF). We used three-dimensional speckle tracking echocardiography (3DSTE) to assess changes in both systolic and diastolic LV function in SCD. Transthoracic real time 3D images were obtained (Philips iE33) in 56 subjects, including 28 stable outpatients with SCD (age 33 ± 7 years) and 28 normal controls (age 35 ± 9 years). 3DSTE was performed using prototype software (4DLV Analysis, TomTec) to obtain LV volume and deformation time curves, from which indices of systolic and diastolic LV function were calculated. In SCD patients, 3DSTE-derived LV filling parameters were significantly different from normal controls, reflecting an increase in both rapid and atrial filling volumes and prolonged active relaxation, depicted by a decrease in filling volume fractions at fixed times and an increase in rapid filling duration. Global LV systolic function was not only preserved but increased compared to controls, as reflected by significantly increa...Continue Reading

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Citations

Jun 24, 2014·The International Journal of Cardiovascular Imaging·Nadjib HammoudiFrançois Lionnet
Sep 7, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Marcia M BarbosaMaria Carmo P Nunes
Jul 16, 2015·Echocardiography·Efstathios D PagoureliasVassilios Vassilikos
Dec 4, 2014·Echocardiography·Khaled HadeedYves Dulac
Mar 3, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Joao Carlos Moron Saes BragaDanielen Cristina Mariano Peluccio
Jan 4, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Michael V Di MariaAdel K Younoszai
Oct 14, 2016·PloS One·Julia H IndikAnkit A Desai
Nov 20, 2018·British Journal of Haematology·Nicholas S WhippleJane S Hankins
May 22, 2020·Journal of Translational Internal Medicine·Marielle MorissensJosé Castro Rodriguez
Jul 6, 2020·The International Journal of Cardiovascular Imaging·Maria Betânia Solis ResendeMaria Carmo Pereira Nunes
Jun 21, 2018·British Journal of Haematology·Marielle MorissensAndre Efira
Dec 14, 2018·Frontiers in Medicine·Aymeric MenetXavier Jouven
Mar 21, 2021·Pediatric Blood & Cancer·Nicholas S WhippleJane S Hankins

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