PMID: 775531Mar 1, 1976

Evaluation of myocardial infarction with enzymatic indices

Progress in Cardiovascular Diseases
G AhumadaB E Sobel

Abstract

The severity of myocardial damage appears to be a common denominator contributing to electrophysiologic derangements, impaired ventricular function, and prognosis after myocardial infarction. Physiologically based models of processes affecting appearance and disappearance of CPK from the circulation may improve predictions and estimates of infarct size. Elevation of serum MB CPK isoenzyme activity appears to be a highly sensitive and specific indicator of myocardial injury. Despite the limitations discussed, recently developed enzymatic methods for detection, projection, and quantification of infarct dize have demonstrated that the extent of myocardial injury may be limited in selected patients by appropriate therapeutic measures. Further investigation may help to define the intervals between the onset of infarction and implementation of therapeutic maneuvers during which myocardial protection is possible, and may help to identify and differentiate inter ventions which salvage myocardium, those which improve cardiac performance without altering infarct size, and those which augment cardiac injury despite improving hemodynamics. Thus, in conjunction with electrophysiologic, radioisotopic, and hemodynamic techniques, enzymatic es...Continue Reading

References

Jan 1, 1987·European Journal of Applied Physiology and Occupational Physiology·J E GravesJ P Norton
Apr 1, 1978·The American Journal of Cardiology·C A TrahernD A Bigham
Feb 21, 1977·European Journal of Pharmacology·A M LeferG H Osman
Feb 1, 1993·Annals of Emergency Medicine·M S EisenbergW D Weaver
Apr 1, 1984·Journal of the American College of Cardiology·D D WatersL Campeau
Jan 1, 1994·Annual Review of Medicine·Y Rozenman, M S Gotsman
Mar 1, 1996·Acta Obstetricia Et Gynecologica Scandinavica·Y AbramovJ Schenker
Nov 26, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Toru MiyoshiShozo Kusachi
Dec 1, 1979·The American Journal of Cardiology·M A DeWoodR Grunwald
Mar 1, 1978·The American Journal of Cardiology·A L GutovitzR Roberts
Jan 1, 1977·The American Journal of Cardiology·B E SobelR Roberts
Sep 1, 1986·Clinical Cardiology·E StoupelJ Agmon
Dec 1, 1988·Australian and New Zealand Journal of Medicine·T O Cheng
Jan 1, 1982·Annals of Emergency Medicine·C C Johnston, E C Bolton
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·C C Foreback, J W Chu
Jun 1, 1982·Critical Reviews in Clinical Laboratory Sciences·R Bais, J B Edwards
Jul 1, 1977·Circulation·J G Greenwald
Jan 1, 1982·Scandinavian Journal of Thoracic and Cardiovascular Surgery·E Hjelms, H Vejlsted
Jan 1, 1985·Basic Research in Cardiology·S YoshidaD M Yellon
Dec 1, 1987·Australian and New Zealand Journal of Medicine·K S Woo

Citations

Jul 1, 1975·Circulation·C R Roe, C F Starmer
Nov 1, 1975·Circulation·R RobertsB E Sobel
Mar 31, 1976·The American Journal of Cardiology·B E SobelK B Larson
Dec 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·P Malmberg
Sep 5, 1974·The New England Journal of Medicine·W E Shell, B E Sobel
Jun 1, 1972·The American Journal of Cardiology·A Konttinen, H Somer
Oct 1, 1972·Circulation·B E SobelR D Yoder
Feb 1, 1968·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·D BurckhardtI Steinberg
Aug 1, 1970·The American Journal of Cardiology·F R ShaftH Imfeld
Apr 1, 1968·The American Journal of Cardiology·J R WarbasseN J Galluzzi
Nov 1, 1968·Archives of Internal Medicine·J S Lafair, R M Myerson
Sep 1, 1965·Journal of Clinical Pathology·P D Griffiths
Jan 1, 1966·Acta Obstetricia Et Gynecologica Scandinavica·U Larsson-Cohn
Mar 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·K J van der Veen, A F Willebrands
Mar 1, 1967·The American Journal of the Medical Sciences·J Eshchar, H J Zimmerman
May 1, 1967·British Heart Journal·R B Hedworth-WhittyR W Richardson
Oct 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·F WROBLEWSKI, J S LADUE
Jan 1, 1959·The American Journal of Cardiology·C M AGRESS
Oct 7, 1961·JAMA : the Journal of the American Medical Association·W E WACKERE AMADOR
Jun 1, 1965·The Journal of Clinical Endocrinology and Metabolism·F A GRAIG, J C SMITH

Related Concepts

Macro-Creatine Kinase
Radioisotopic
Myocardium
Myocardial Infarction
Adsorption
Cardiomyopathies
Ventricular Function
Brain Damage, Chronic
Cell Survival
Hemodynamics

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