Evaluation of myocardial perfusion reserve in patients with CAD using contrast-enhanced MRI: a comparison between semiquantitative and quantitative methods

RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
M SchmittW G Schreiber

Abstract

Comparison between two semiquantitative methods and a quantitative evaluation of myocardial blood flow (MBF) for assessment of myocardial perfusion reserve (MPR) in patients with CAD. 9 patients with coronary stenoses > 50 % were examined with an ECG-gated Saturation Recovery Turbo FLASH sequence by using Gd-DTPA as contrast agent (CA). The entive measurements were performed both during rest and hyperemia induced by adenosine. The up-slopes of the signal-time S(t) curves in the myocardium and left ventricular (LV) cavity were evaluated by a linear fit. MPR was calculated from the original up-slopes of the myocardial S(t) curves and from the up-slopes, which were normalized to the up-slopes of the LV S(t) curves, respectively. For quantification of MBF values, the mathematical model MMID 4 was used and MPR was evaluated from the MBF values. With all tested methods, MPR was reduced in myocardial regions subtended by arteries with stenoses >/= 70 % compared with remote regions. With MMID 4 and the normalized up-slope method, differences between severe ischemic and remote regions were statistically significant. The up-slope method with normalization and quantification with MMID 4 are more sensitive methods to differentiate between ...Continue Reading

Citations

Oct 29, 2008·IEEE Transactions on Medical Imaging·Anja HennemuthHeinz-Otto Peitgen
Jun 2, 2004·Journal of Magnetic Resonance Imaging : JMRI·Jörg BarkhausenJörg F Debatin
Sep 13, 2002·NMR in Biomedicine
May 4, 2006·European Radiology·Peter HunoldJörg Barkhausen
Jul 20, 2017·Zeitschrift für Gerontologie und Geriatrie·Helmut FrohnhofenNikolaus Netzer

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